Results 91 to 100 of about 3,631,850 (311)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

IMPLEMENTATION OF MERDEKA MANDIRI CURRICULUM CHANGES IN ISLAMIC RELIGIOUS EDUCATION LEARNING AT UPT SMP NEGERI 2 GRESIK

Lisan Al-Hal: Jurnal Pengembangan Pemikiran dan Kebudayaan
The Merdeka Mandiri curriculum is the curriculum chosen by UPT SMP Negeri 2 Gresik to implement the independent curriculum initiated by the Minister of Education and Culture, Nadiem Makarim.
Fia Ayu Putri Agustin, Amrullah Amrullah, Abd. Muqit, Usman Yudi   +3 more
doaj   +1 more source

ANALYSIS OF THE QUALITY OF PHYSICS TEXTBOOKS IN THE 2013 CURRICULUM AND THE INDEPENDENT CURRICULUM

EduFisika: Jurnal Pendidikan Fisika
Similar things have also been done to support the implementation of the previous curriculum, namely the School Unit Level Curriculum and the 2023 Curriculum. This study aims to compare the quality of physics textbooks recognized by the Government in the 2013 Curriculum and the Independent Curriculum.
Jaya Putra, Don, Algiranto, Algiranto, Ekasari, Aprilita, Inyang, Francis   +3 more
openaire   +2 more sources

Report of an independent peer review of A forest management strategy for the proposed Coquille Forest submitted to the Coquille Indian Tribe by the Independent Scientific Advisory Team (ISAT)

, 1995
"[T]he [Coquille Indian] Tribe requested that the State of Oregon assemble a team of independent scientists to peer review the forest management strategy proposed by the ISAT.

core  

Contemporary Analysis on Curriculum Theorists in Education

This is a book review for CURRICULUM WINDOWS REDUX: WHAT CURRICULUM THEORISTS CAN TEACH US ABOUT SCHOOLS AND SOCIETY TODAY, edited by Thomas S. Poetter, Kelly Waldrop, and Syed Hassan Raza (2022).
Tan, Jing
core   +1 more source

Engaging Texts Today or How to Read a Curriculum Poem [PDF]

, 2020
The JCT Engaging Texts Section Editor writes about her vision for the Section and its importance to contemporary curriculum ...
Tarc, Aparna Mishra
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Evaluation Of The Implementation Of The Independent Curriculum

Eduvest - Journal of Universal Studies
The implementation of the Independent Curriculum in driving schools is a strategic step by the Ministry of Education and Culture in facing the challenges of the 21st century, which emphasizes competency-based learning, differentiation, and character. In this context, the subjects of Physical Education, Sports, However, the implementation of this new ...
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Implementasi Pembelajaran IPAS Terintegrasi Keterampilan Abad 21 dalam Kurikulum Merdeka

Dawuh Guru
Changes in subjects in the independent curriculum in Elementary Schools (SD)/MI include science and social studies subjects becoming Natural and Social Sciences (IPAS).
Farikhatun Nikmah, Muzdalifah Muzdalifah, Agus Retnanto   +2 more
doaj   +1 more source