Results 71 to 80 of about 74,170 (261)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Implementation of Merdeka Curriculum in Accounting Learning at SMK Negeri 6 Sukoharjo

Jurnal AKSI (Akuntansi dan Sistem Informasi)
The independent curriculum based on Pancasila student profiles prioritizes student learning outcomes. The purpose of this study was to provide a description of the management of accounting learning in the independent curriculum, including (1) planning ...
Dian Fadhila, Moh. Chairil Asmawan
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

IMPLEMENTATION OF MERDEKA MANDIRI CURRICULUM CHANGES IN ISLAMIC RELIGIOUS EDUCATION LEARNING AT UPT SMP NEGERI 2 GRESIK

Lisan Al-Hal: Jurnal Pengembangan Pemikiran dan Kebudayaan
The Merdeka Mandiri curriculum is the curriculum chosen by UPT SMP Negeri 2 Gresik to implement the independent curriculum initiated by the Minister of Education and Culture, Nadiem Makarim.
Fia Ayu Putri Agustin, Amrullah Amrullah, Abd. Muqit, Usman Yudi   +3 more
doaj   +1 more source

Analysis of the Implementation of the Love Curriculum Replacing the Independent Curriculum in Madrasah

Edunesia : Jurnal Ilmiah Pendidikan
The Independent Curriculum, implemented nationally since 2022, is viewed as not fully meeting the needs of Islamic education, which prioritizes the development of students’ spiritual, moral, and practical character. In the Madrasah context, a curriculum model is required that more explicitly integrates values of compassion, empathy, and love for God ...
Chanifudin Chanifudin, Halimatu Sa'diah, Rini Nopita, Suswanto Suswanto   +3 more
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Implementasi Pembelajaran IPAS Terintegrasi Keterampilan Abad 21 dalam Kurikulum Merdeka

Dawuh Guru
Changes in subjects in the independent curriculum in Elementary Schools (SD)/MI include science and social studies subjects becoming Natural and Social Sciences (IPAS).
Farikhatun Nikmah, Muzdalifah Muzdalifah, Agus Retnanto   +2 more
doaj   +1 more source

Implementation of the Independent Curriculum: Educational Innovation that Encourages Learning Independence

International Journal of Applied Educational Research (IJAER)
This study aims to analyze the implementation of the Independent Curriculum in Madrasah Aliyah Negeri 2 Palembang using a qualitative descriptive approach. This research involves subject teachers, madrasah heads, curriculum waka, and students as key and supporting informants.
null Annisa Wahyuni, M. Hasbi, Rabial Kanada   +2 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Implementation of the Independent Sharing Independent Curriculum in Early Childhood Education

JPI (Jurnal Pendidikan Indonesia)
The problem in this research focuses on the implementation of the Independent Curriculum, independent sharing, freeing up early childhood education units in implementing the Independent Curriculum by developing their own teaching tools. However, there are still many who are not ready because the implementation of the Independent Curriculum is different
null Afriana, null Nelva Rolina
openaire   +1 more source