Results 71 to 80 of about 3,631,850 (311)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Curriculum Journal Index - 1929-1943

, 2021
This number of Curriculum History 2021 is an index - name/article title - to the publication, Curriculum Journal, published by the Society for Curriculum Study between 1929 and 1943 when the organization ceased to exist, becoming a founding part of the ...
Burlbaw, Lynn Matthew
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evaluating the Implementation of the Independent Curriculum Policy in Indonesia: Sentiment Analysis

Studies in Learning and Teaching
Problems still occur in the implementation of the curriculum that changed to the Independent Curriculum, which aims to give freedom to schools, teachers and students. However, in its implementation there are still problems experienced by schools.
Muhamad Sholeh, Bambang Sigit Widodo, Bima Anggana Widhiarta Putra   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Problem-based learning in improving critical mathematical thinking skills: Independent curriculum teaching module

Al-Jabar
Background: Students' limited abilities in critical mathematical thinking present a persistent obstacle in mathematics education. To address this issue, this study focuses on developing a teaching module aligned with the Independent Curriculum ...
Helmira Juniati, Elita Zusti Jamaan
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Role of The LCGC (Low Cost Great Curriculum) Model on Teacher Performance in The Implementation of The Independent Curriculum

Jurnal Paedagogy
This study aims to analyze the role of the LCGC (low cost great curriculum) model on teacher performance in implementing the Merdeka curriculum in Madrasah. This study used a quantitative approach with an associative correlational design.
Azmy Ali Muchtar, Marhamah Marhamah, Popi Puadah   +2 more
doaj   +1 more source

Engaging Mister Rogers' Neighborhood as a "Great" Curriculum: A Curriculum Critique

Fred Rogers was a master pedagogue and his magnum opus, Mister Rogers’ Neighborhood, is an exemplary progressive curriculum that endures as a “great curriculum” (Poetter, 2011).
Talbert, Kevin M
core   +1 more source

Disability Plots: Curriculum, Allegory, & History

, 2019
This article discusses theoretical approaches from disability studies and curriculum studies to help educators see how we position the experiences of, and discourses about, people with disabilities in the various narratives we recreate about “America ...
Helmsing, Mark
core   +1 more source