Results 61 to 70 of about 74,170 (261)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fathers’ Experiences of Juggling Work and Family Life in Abu Dhabi Workplaces

Social Sciences
In academic literature, fathers often cite barriers related to their employment, which may halt or negatively influence their level of involvement with their children. This is sometimes reported in relation to practices and policies around leave, such as
Martina Dickson, Jessica Midraj, Melissa McMinn, Hala Sukkar, Maram Alharthi, Barbara Read   +5 more
doaj   +1 more source

Policy Analysis of The Independent Curriculum In Indonesia

Syntax Literate ; Jurnal Ilmiah Indonesia, 2023
The changes taking place in this world are very fast. The change affects everything in it. Including in the world of education. The condition of the world that is slowly moving back after the COVID-19 pandemic requires us to quickly respond to existing changes. For this recovery is carried out on all parties.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Role of The LCGC (Low Cost Great Curriculum) Model on Teacher Performance in The Implementation of The Independent Curriculum

Jurnal Paedagogy
This study aims to analyze the role of the LCGC (low cost great curriculum) model on teacher performance in implementing the Merdeka curriculum in Madrasah. This study used a quantitative approach with an associative correlational design.
Azmy Ali Muchtar, Marhamah Marhamah, Popi Puadah   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Development of an Islamic-Based Independent Curriculum Based on the National Curriculum

Journal Research of Social Science, Economics, and Management
The background of this research is a study of how to develop an Islamic-based curriculum in informal education in order to provide options and solutions to create an Islamic-based curriculum to develop quality education. The purpose of this research is to develop a curriculum and meet the needs of the community in Islamic educational institutions.
Daryatmo Rahman, R. Madhakomala
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ANALYSIS OF THE QUALITY OF PHYSICS TEXTBOOKS IN THE 2013 CURRICULUM AND THE INDEPENDENT CURRICULUM

EduFisika: Jurnal Pendidikan Fisika
Similar things have also been done to support the implementation of the previous curriculum, namely the School Unit Level Curriculum and the 2023 Curriculum. This study aims to compare the quality of physics textbooks recognized by the Government in the 2013 Curriculum and the Independent Curriculum.
Jaya Putra, Don, Algiranto, Algiranto, Ekasari, Aprilita, Inyang, Francis   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source