Results 71 to 80 of about 8,253 (248)

Improved Upper Bound on Independent Domination Number for Hypercubes

, 2022
We revisit the problem of determining the independent domination number in hypercubes for which the known upper bound is still not tight for general dimensions. We present here a constructive method to build an independent dominating set $S_n$ for the $n$
Chowdhury, Debabani, Bhattacharya, Bhargab B., Das, Debesh K.   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Triangle-free graphs with large independent domination number

, 2010
Let G be a simple graph of order n and minimum degree δ. The independent domination number i(G) is defined as the minimum cardinality of an independent dominating set of G. We prove the following conjecture due to Haviland [J.
Chen, Xue-gang, Chan, Wai Hong, Shiu, Wai Chee   +2 more
core   +1 more source

Weak edge-degree domination in hypergraphs [PDF]

, 1979
summary:In this paper we extend the notion of weak degree domination in graphs to hypergraphs and find relationships among the domination number, the weak edge-degree domination number, the independent domination number and the independence number of a ...
B.D. Acharya, Acharya, B.D., Gupta, Purnima, Acharya, Belmannu Devadas   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Fuzzy Graphs With Equal Fuzzy Domination And Independent Domination Numbers

, 2013
The basic definitions of fuzzy independent set, fuzzy dominating set,and fuzzy independent dominating sets are discussed. The aim of this paper is to find on what conditions the fuzzy graph has equal domination number and independent domination number ...
Nagoorgani, A.; P.G. & Research Department of Mathematics, Vijayalakshmi, P.; Department of Mathematics   +1 more
core  

Independent domination number in Cayley digraphs of rectangular groups

, 2018
Let [Formula: see text] denote the Cayley digraph of the rectangular group [Formula: see text] with respect to the connection set [Formula: see text] in which the rectangular group [Formula: see text] is isomorphic to the direct product of a group, a ...
Nuttawoot Nupo, Sayan Panma
core   +1 more source