Results 61 to 70 of about 8,253 (248)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
On independent domination and packing numbers of subcubic graphs
Applied Mathematics and ComputationIn a recent paper, Cho and Kim proved that in subcubic graphs, the independent domination number is at most three times the packing number. They subsequently posed the question of characterizing subcubic graphs that achieve this bound. In this paper, we completely solve the question by proving that exactly four graphs meet this bound.
Xuqing Bai +3 more
openaire +2 more sources
On upper bounds for the independent transversal domination number
Discrete Applied Mathematics, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Christoph Brause +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Independent domination in graphs
, 2018 V magistrskem delu obravnavamo različne tipe dominacij in sicer dominantno število, neodvisnostno število, neodvisno dominantno število in zgornje dominantno število.
Črešnjevec, Nina
core
The domination parameters of cubic graphs [PDF]
, 2005 Let ir(G), γ(G), i(G), β0(G), Γ(G) and IR(G) be the irredundance number, the domination number, the independent domination number, the independence number, the upper domination number and the upper irredundance number of a graph G, respectively.
Zverovich, Vadim, Zverovich, Igor E.
core +1 more source
THE NUMBER OF INDEPENDENT DOMINATING SETS OF LABELED TREES [PDF]
Communications of the Korean Mathematical Society, 2003 Summary: We count the numbers of independent dominating sets of rooted labeled trees, ordinary labeled trees, and recursive trees, respectively.
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source