Results 91 to 100 of about 6,699,010 (307)

Four million COVID-19 cases in four European cross-border regions reveal minimal cross-border transmission effect on domestic burden: space-time cluster analysis

BMC Infectious Diseases
Introduction Restrictions of cross-border mobility were used during the COVID-19 pandemic to slow down transmission between countries. Such restrictions came with significant societal costs, and their effect on in-country burdens of COVID-19 has been ...
Brigitte van der Zanden, Boris Kauhl, Volker Hackert, Christian JPA Hoebe   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Home modifications: important for fall injury prevention for Māori in New Zealand

The Lancet Public Health, 2021
Keith D Hill
doaj   +1 more source

Living Independently [PDF]

, 2017
Objectives:\ud The aim of this study is to gain a deeper understanding of the experiences of visually impaired older people living independently at home.\ud \ud Background:\ud As populations are aging globally, there is now an increase in the prevalence of visual impairment.
Rooney, C., Hadjri, K., Faith, V., Rooney, M., McAllister, K., Craig, C.   +5 more
openaire  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Transition to Independent Living for Young Adults with Intellectual Disability: A Scoping Review

Scandinavian Journal of Disability Research
Background: The transition to adulthood represents a pivotal period for young adults with intellectual disabilities. Yet limited research exists on how their lived experiences align with the right to independent living as enshrined in Article 19 of the ...
Iselin Evensen, Line Melboe, Anita Borch
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Correction to: Self-managed occupational therapy and physiotherapy for adults receiving inpatient rehabilitation (‘My Therapy’): protocol for a stepped-wedge cluster randomised trial

BMC Health Services Research, 2021
Natasha K. Brusco, Christina L. Ekegren, Nicholas F. Taylor, Keith D. Hill, Annemarie L. Lee, Lisa Somerville, Natasha A. Lannin, Derick Wade, Rania Abdelmotaleb, Libby Callaway, Sara L. Whittaker, Meg E. Morris   +11 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source