Results 111 to 120 of about 3,018,784 (306)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Functional Independence of Taiwanese Children with Silver–Russell Syndrome

Diagnostics
Background: Silver–Russell syndrome (SRS) is a genetic disorder characterized by prenatal and postnatal growth retardation. Affected individuals commonly present with low birth weight, intrauterine growth restriction, postnatal short stature ...
Hung-Hsiang Fang, Chung-Lin Lee, Chih-Kuang Chuang, Huei-Ching Chiu, Ya-Hui Chang, Yuan-Rong Tu, Yun-Ting Lo, Jun-Yi Wu, Yen-Yin Chou, Chung-Hsing Wang, Shio-Jean Lin, Shao-Yin Chu, Chen Yang, Tsung-Ying Ou, Hsiang-Yu Lin, Shuan-Pei Lin   +15 more
doaj   +1 more source

ATHENE : Assistive technologies for healthy living in elders : needs assessment by ethnography [PDF]

, 2011
Numerous assistive technologies to support independent living –including personal alarms, mobile phones, self-monitoring devices, mobility aids, software apps and home adaptations –have been developed over the years, but their uptake by older people ...
Dewsbury, Guy, Greenhalgh, Trisha, Procter, Rob, Rouncefield, Mark, Wherton, Joe   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

IMProving older people’s health through physical ACTivity: the implementation of a community-based framework to promote park-based active ageing

BMC Public Health
Background Outdoor environments such as recreational spaces with age-friendly exercise equipment offer promising and sustainable approaches to promote physical activity among older people.
Pazit Levinger, Marcia Fearn, Bronwyn Dreher, Adrian Bauman, Sze-Ee Soh, Natasha K. Brusco, Andrew Gilbert, Rachel Muoio, Elissa Burton, Keith Hill   +9 more
doaj   +1 more source

The Exchange Rate, Productivity, and the Standard of Living [PDF]

This article examines the recent proposition that the decline in Canada's standard of living relative to that of the United States is causally related to the decline in our exchange rate.
Lawrence L. Schembri, Robert Lafrance
core  

Aids to independent living for the blind (1993) [PDF]

, 1993
"Reviewed October 1993.
Vaughan, C. Edwin
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Independent Living for people with disabilities: from patient to citizen and customer [PDF]

, 2007
[Excerpt] I want to suggest that differences in the attitudinal and material conditions determine disabled peoples’ life opportunities, how dependent or independent we can become.
Ratzka, Adolf
core   +1 more source