Results 91 to 100 of about 147,811 (320)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Experimental assessment of coagulation efficiency using aluminum and iron salts [PDF]

open access: yesE3S Web of Conferences
A comprehensive experimental study of the comparative efficiency of traditional and modern coagulants for model wastewater treatment was conducted. The work examined in detail four types of reagents: aluminum sulfate (Al2(SO4)3), iron (III) chloride ...
Sergiyanskiy Evgeniy
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Realized volatility and absolute return volatility: a comparison indicating market risk [PDF]

open access: yes, 2014
Measuring volatility in financial markets is a primary challenge in the theory and practice of risk management and is essential when developing investment strategies.
Li, Baowen   +4 more
core   +3 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Reagent-free detection of Plasmodium falciparum malaria infections in field-collected mosquitoes using mid-infrared spectroscopy and machine learning

open access: yesScientific Reports
Field-derived metrics are critical for effective control of malaria, particularly in sub-Saharan Africa where the disease kills over half a million people yearly.
Emmanuel P. Mwanga   +13 more
doaj   +1 more source

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]

open access: yes, 2012
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Adegbola, Richard A   +18 more
core   +2 more sources

The comparison of laboratory and industrial copper ore upgrading indices during introduction of new flotation reagents

open access: yesIOP Conference Series: Materials Science and Engineering, 2019
Abstract This article draws attention to the need for the introduction of a laboratory testing methodology for new flotation reagents prior to the implementation of them for industrial use which would be more effective than the one currently used.
P. Kurzydło, M. Krzemińska, W. Pawlos
openaire   +2 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

Treatment and Recycling of Tungsten Beneficiation Wastewater: A Review

open access: yesSeparations
The large amount of wastewater containing various pollutants generated during the tungsten beneficiation process has become a bottleneck for the sustainable development of tungsten mining enterprises.
Wenxia Zhu   +6 more
doaj   +1 more source

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