Results 51 to 60 of about 2,085,056 (273)

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Cross-reaction test by indirect ELISA.

, 2021
Cross-reaction test by indirect ELISA.
Riccardo Marega (2121085), David Poirier (1541152), Nathalie Gillard (2560384), Philippe Delahaut (361763), Jérémie Théolier (11473228), Samuel Benrejeb Godefroy (11473231)   +5 more
core   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Application of Monoclonal Antibodies Developed Against the IpaJ Protein for Detection of Chickens Infected With Salmonella enterica Serovar Pullorum Using Competitive ELISA

Frontiers in Veterinary Science, 2019
Pullorum disease remains an epidemic in the poultry industry in China. The causing pathogen is a host-restricted Salmonella enterica serovar Pullorum, which can spread through both horizontal and vertical transmissions.
Kequan Yin, Kequan Yin, Kequan Yin, Jingwei Ren, Jingwei Ren, Jingwei Ren, Yue Zhu, Yue Zhu, Yue Zhu, Lijuan Xu, Lijuan Xu, Lijuan Xu, Chao Yin, Chao Yin, Chao Yin, Yang Li, Yang Li, Yang Li, Yu Yuan, Yu Yuan, Yu Yuan, Qiuchun Li, Qiuchun Li, Qiuchun Li, Xinan Jiao, Xinan Jiao, Xinan Jiao   +26 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Development of a competitive indirect ELISA for high-throughput screening of hydrocortisone in cosmetic sample

Food and Agricultural Immunology, 2019
Hydrocortisone (HYD) is one of the corticosteroids that illegally used in cosmetic products, which could lead to a potential health problem. In this work, HYD was conjugated to bovine serum albumin via a succinic anhydride spacer arm to yield an ...
Shiwei Zhang, Zhuo-Yu Wu, Kai Zhou, Lin Luo, Zhen-Lin Xu   +4 more
doaj   +1 more source

Development and validation of a sensitive enzyme-linked immunosorbent assay for clonidine hydrochloride in pig urine and pork samples

Food and Agricultural Immunology, 2021
Clonidine hydrochloride (CLO) is a new substitute for a traditionally used adrenergic agonist. The illegal use of CLO in the livestock industry possess potential harm to human health.
Yao Wang, Jinbo Cao, Yaning Sun, Yunrui Xing, Xinghao Pang, Xiujin Chen, Peng Fei, Zhaozhou Li, Qiaofen Cheng, Huaibin Kang, Xiaofei Hu   +10 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Research on the Mechanism of Action of a Citrinin and Anti-Citrinin Antibody Based on Mimotope X27

Toxins, 2020
Immunoassays are developed based on antigen–antibody interactions. A mimotope is an effective recognition receptor used to study the mechanism of action of antigens and antibodies, and is used for improving the sensitivity of the antibody. In this study,
Yanping Li, Yucheng Hu, Zhui Tu, Zhenqiang Ning, Qinghua He, Jinheng Fu   +5 more
doaj   +1 more source

Detection of Clostridium perfringens type D epsilon antitoxin in serum of goats by competitive and indirect ELISA

, 1997
Indirect and competitive ELISA techniques were developed and their ability to detect antibodies to Clostridium perfringens epsilon toxin in goat serum was compared, Different dilutions of a hyperimmune goat serum, in serum from a colostrum-deprived kid ...
F.A. Uzal, Nielsen, K., K. Nielsen, Uzal, F. A., Kelly, W. R., W.R. Kelly   +5 more
core   +1 more source