Results 21 to 30 of about 2,897,143 (280)

HealthSWEDE: costs with sublingual immunotherapy—a Swedish questionnaire study

open access: yesAllergy, Asthma & Clinical Immunology, 2021
Background The aim of this cross-sectional survey was to compare the health-economic consequences for allergic rhinitis (AR) patients treated with sublingual Immunotherapy (SLIT) in terms of direct and indirect costs with a reference population of ...
Petter Olsson   +8 more
doaj   +1 more source

Economic Burden of Colorectal Cancer: A Scoping Review [PDF]

open access: yesپیاورد سلامت, 2023
Background and Aim: Colorectal cancer is one of the most common cancers that its incidence and prevalence and so deaths due to this cancer have increased worldwide recently.
Keyhan Fatehi   +2 more
doaj  

Indirect economic costs of avoidable mortality in Moldova

open access: yesActa Universitatis Carolinae Geographica, 2021
In this article, we carry out the cost-analysis of the total premature mortality and avoidable causes of death for Moldova by applying the human capital approach. The results show that the indirect costs of avoidable mortality represent slightly over 85%
Irina Pahomii
doaj   +1 more source

Calculating indirect costs from international PEPFAR implementing partners. [PDF]

open access: yesPLoS ONE, 2018
BACKGROUND:UNAIDS estimates global HIV investment needs in low- and middle-income countries (LMICs) at $26 billion per year in 2020. Yet international financing for HIV programs has stagnated amidst despite the increasing number of people requiring and ...
Brian Honermann   +9 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Disease activity, quality of life, and indirect costs of ulcerative colitis in Poland [PDF]

open access: yes, 2017
Introduction : Ulcerative colitis (UC) require expensive, lifelong treatment, which generates huge direct costs and has a significant impact on the quality of life, especially in the active state of the disease.
Stawowczyk, Ewa   +7 more
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

open access: yesMolecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis   +20 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Main challenges in the identification and measurement of indirect costs in projects: a multiple case study [PDF]

open access: yesGestão & Produção, 2020
Projects have direct and indirect costs; the direct ones are easily identified and quantified, the indirect ones are difficult to control, because they are generated in favor of more than one project, and even if they are not directly related to the ...
Bruno Cardoso Faria   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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