Results 31 to 40 of about 1,121,948 (298)

Using Space Syntax For Estimation Of Potential Disaster Indirect Economic Losses [PDF]

open access: yes, 2016
The study of applicable network measures shows that Normalised Angular Choice can be used as criteria for selecting alternatives for minimizing indirect costs caused by road network damages.
Penchev, Georgi
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Premature Mortality and Years of Potential Life Lost Due to Diabetes Mellitus

open access: yesEndocrinology Research and Practice, 2022
The aim of the study is to compute, Years of Potential Life Lost attributed to diabetes mellitus, as a measure of premature mortality. In 1994, the total 1993 year deaths of Bornova Education and Research District were determined by screening the death ...
Erhan Eser
doaj   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

The socioeconomic impact of multiple sclerosis in France: Results from the PETALS study

open access: yesMultiple Sclerosis Journal - Experimental, Translational and Clinical, 2022
Background Multiple sclerosis (MS) places a considerable financial burden on the society. However, data quantifying the contemporary cost burden in France are lacking.
A Bouleau   +11 more
doaj   +1 more source

Factors influencing the identification of it indirect costs: A case study [PDF]

open access: yes, 2008
Organizations expenditure on Information technology (IT) related investments continue to rise in the face of the fierce competition in the various marketplaces.
Ghoneim, A
core  

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao   +7 more
wiley   +1 more source

The economic burden of atopic dermatitis in Romania: a broad perspective

open access: yesFrontiers in Public Health
IntroductionAtopic dermatitis (AD), a common dermatological condition, is often associated with significant economic and social burdens. Despite extensive studies globally, there is a gap in understanding the impact of this condition in Romania.
Alin Codruț Nicolescu   +7 more
doaj   +1 more source

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