Results 111 to 120 of about 2,682,331 (306)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Simulation of Radiation-Induced DNA Damage and Protection by Histones Using the Code RITRACKS

BioTech
(1) Background: DNA damage is of great importance in the understanding of the effects of ionizing radiation. Various types of DNA damage can result from exposure to ionizing radiation, with clustered types considered the most important for ...
Ianik Plante, Devany W. West, Jason Weeks, Viviana I. Risca   +3 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The ‘Indirect’ Effects of Cytomegalovirus Infection

American Journal of Transplantation, 2009
Cytomegalovirus (CMV) remains the most important infection in the immunocompromized host even in the era of effective therapy. CMV is usually acquired early in life and can be transmitted by contact with infected body fluids. In the immunocompetent population, primary infection is almost always of little clinical consequence.
openaire   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

The Stolper-Samuelson Theorem Reconsidered: An Example of Ricardian Dynamic Trade Effects [PDF]

Standard trade theory views the capital stock as an endowment. However, trade policy can affect a country's steady-state capital stock. By ignoring the endogeneity of capital, standard analysis is incomplete and can be misleading.
Richard E. Baldwin
core  

Aerosol indirect effects

, 2015
Aerosol indirect effects continue to constitute one of the most important uncertainties for anthropogenic climate perturbations. Within the international AEROCOM initiative, the representation of aerosol-cloud-radiation interactions in ten different general circulation models (GCMs) is evaluated using three satellite datasets.
Quaas, Johannes, Ming, Yi, Menon, Surabi, Takemura, Toshihiko, Wang, M., Penner, Joyce E., Gettelman, Andrew, Lohmann, Ulrike, Bellouin, Nicolas, Boucher, Olivier, Sayer, Andrew M., Thomas, G. E., McComiskey, Allison, Feingold, Graham, Hoose, Corinna, Kristjansson, Jon Egill, Liu, Xiaohong, Balkanski, Yves, Donner, Leo J., Ginoux, Paul A., Stier, Philip, Grandey, Benjamin, Feichter, Johann, Sednev, Igor, Bauer, Susanne E., Koch, Dorothy, Grainger, Roy Gordon, Kirkevag, Alf, Iversen, Trond, Seland, Ø., Easter, Richard, Ghan, Steven J., Rasch, Philip J., Morrison, Hugh, Lamarque, Jean-Francois, Iacono, Michael J., Kinne, Sebastian, Schulz, M.   +37 more
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Direct, indirect, and interaction effects based on principal stratification with a binary mediator

Journal of Causal Inference
Given a binary treatment and a binary mediator, mediation analysis decomposes the total effect of the treatment on an outcome variable into various sub-effects, and there appeared two-, three-, and four-way decompositions in the literature.
Lee Myoung-jae
doaj   +1 more source