Results 111 to 120 of about 2,702,302 (307)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Simulation of Radiation-Induced DNA Damage and Protection by Histones Using the Code RITRACKS
BioTech(1) Background: DNA damage is of great importance in the understanding of the effects of ionizing radiation. Various types of DNA damage can result from exposure to ionizing radiation, with clustered types considered the most important for ...
Ianik Plante +3 more
doaj +1 more source
Approximate properties of the response of nonlinear dynamic systems to stochastic inputs [PDF]
, 1971 Indirect method considers effect of nonlinearity and obtains approximate probability densities of certain characteristics, from these densities various statistical properties are calculated. Direct method determines response moments directly.
Zirkle, L. D.
core +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Inequality aversion and externalities [PDF]
We conduct a general analysis of the effects of inequality aversion on decisions by homogeneous players in static and dynamic games. We distinguish between direct and indirect effects of inequality aversion.
Gürtler, Marc, Gürtler, Oliver
core
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Comment on "Impossibility of distant indirect measurement of the quantum Zeno effect"
, 2005 In the paper by M. Hotta and M. Morikawa [Phys. Rev. A 69, 052114 (2004)] the non-existence of the quantum Zeno effect caused by indirect measurements has been claimed.
Toschek, P. E., Wallentowitz, S.
core +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Direct, indirect, and interaction effects based on principal stratification with a binary mediator
Journal of Causal InferenceGiven a binary treatment and a binary mediator, mediation analysis decomposes the total effect of the treatment on an outcome variable into various sub-effects, and there appeared two-, three-, and four-way decompositions in the literature.
Lee Myoung-jae
doaj +1 more source