Results 51 to 60 of about 2,682,331 (306)

On relation between separable indirect effect, natural indirect effect, and interventional indirect effect

Recently, the separable indirect effect (SIE) has gained attention due to its identifiability without requiring the untestable cross-world assumption necessary for the natural indirect effect (NIE). This article systematically compares the causal assumptions underlying the SIE, NIE, and interventional indirect effect (IIE) and evaluates their ...
Chen, Yan-Lin, Lin, Sheng-Hsuan
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PATH COEFFICIENT ANALYSIS G39×CIHERANG AND MENTIK WANGI×G39 RICE IN F4 GENERATION

AGRIVITA Journal of Agricultural Science, 2014
Current research was conducted with the objectives to identify the utmost traits that may be beneficial for the higher productivity of the grains on high protein content genotypes lines by path coefficient.
Totok Agung D.H., Fuad Nur Azis, Ponendi Hidayat, Dyah Susanti, Agus Riyanto, Shao Hui Zheng   +5 more
doaj  

Environmental stress mediates trophic cascade strength and resistance to invasion

Ecosphere, 2016
Although much attention has focused on the drivers of trophic cascade strength among systems (e.g., habitat type, body size, predator, and prey thermy) comparatively little is known of how trophic cascades change within systems, especially with respect ...
Brian S. Cheng, Edwin D. Grosholz
doaj   +1 more source

Giant magnetocaloric effect driven by indirect exchange in magnetic multilayers

, 2018
Indirect exchange coupling in magnetic multilayers, also known as the Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction, is known to be highly effective in controlling the interlayer alignment of the magnetization.
Holmgren, E., Korenivski, V., Kravets, A. F., Polishchuk, D. M., Tovstolytkin, A. I., Tykhonenko-Polishchuk, Yu. O.   +5 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The conditional process model of mindfulness and emotion regulation: An empirical test [PDF]

, 2017
BACKGROUND: The conditional process model (CPM) of mindfulness and emotion regulation posits that specific mediators and moderators link these constructs to mental health outcomes.
Andrews, Leigh, Curtiss, Joshua, Hofmann, Stefan G., Ito, Masaya, Klemanski, David H.   +4 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source