Results 51 to 60 of about 2,272,890 (294)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Efficient computation of the inverse of gametic relationship matrix for a marked QTL

Genetics Selection Evolution, 2006
Best linear unbiased prediction of genetic merits for a marked quantitative trait locus (QTL) using mixed model methodology includes the inverse of conditional gametic relationship matrix (G-1) for a marked QTL.
Iwaisaki Hiroaki, Sargolzaei Mehdi, Colleau Jean-Jacques   +2 more
doaj   +1 more source

A Neural Network Warm-Started Indirect Trajectory Optimization Method

Aerospace, 2022
The mission of spacecraft usually faces the problem of an unknown deep space environment, limited long-distance communication and complex environmental dynamics, which brings new challenges to the intelligence level and real-time performance of ...
Jianlin Shi, Jinbo Wang, Linfeng Su, Zhenwei Ma, Hongbo Chen   +4 more
doaj   +1 more source

Input Efficiency for Influencing Swarm [PDF]

, 2012
Many cooperative control problems ranging from formation following, to rendezvous to flocking can be expressed as consensus problems. The ability of an operator to influence the development of consensus within a swarm therefore provides a basic test of ...
Amirpour Amraii, Saman, Chakraborty, Nilanjan, Lewis, Michael   +2 more
core   +1 more source

A False Start in the Race Against Doping in Sport: Concerns With Cycling’s Biological Passport [PDF]

, 2011
Professional cycling has suffered from a number of doping scandals. The sport’s governing bodies have responded by implementing an aggressive new antidoping program known as the biological passport.
A Blomqvist, A Laviano, AA Butler, AE Majeski, AJ Cooper, AM Cuervo, AS Chen, AS Chen, B Islam-Ali, C Deans, C Post, CK Lee, D Schmoll, DE Cummings, DL Marks, DL Rothman, E Meimaridou, EA Siess, H Baker, H Shinyama, H Wiesinger, HD Mulligan, HH Wu, I Bosaeus, J Gelin, J Ruud, J Ruud, J Ruud, JA Tayek, JH Shaw, JJ Body, JM Argilés, JM Mercader, JP Konsman, K Fearon, K Ohinata, KD Carr, KF Sheu, L Pourtau, L Tretter, MJ Tisdale, MJ Tisdale, MM Hadjimarkou, OH Lowry, PF Finn, R Ihnatko, R Toni, S Chen, S Desai, S Klein, SJ Orenstein, T Komatsu, T Sato, W Wang, W Wang, W Wang, Y Sugimoto, YX Tao   +57 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Indirect methods for wake potential integration [PDF]

Physical Review Special Topics - Accelerators and Beams, 2006
The development of the modern accelerator and free-electron laser projects requires to consider wake fields of very short bunches in arbitrary three dimensional structures. To obtain the wake numerically by direct integration is difficult, since it takes a long time for the scattered fields to catch up to the bunch.
openaire   +4 more sources

Robust estimation of stationary continuous-time ARMA models via indirect inference

, 2019
In this paper we present a robust estimator for the parameters of a continuous-time ARMA(p,q) (CARMA(p,q)) process sampled equidistantly which is not necessarily Gaussian. Therefore, an indirect estimation procedure is used.
Benth FE, Bradley RC, Martin DR, Martin DR, Martin DR, Pollard D, Yu J   +6 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source