Results 61 to 70 of about 2,266,638 (297)

Extreme Theory of Functional Connections with Receding Horizon Control for Aerospace Applications

Mathematics
This paper introduces a novel closed-loop optimal controller that integrates the Extreme Theory of Functional Connections (X-TFC) with receding horizon control (RHC), referred to as X-TFC-RHC. The controller reformulates a sequence of linearized or quasi-
Kristofer Drozd, Roberto Furfaro
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The Direct and The Indirect as Paired Forensic Categories

Вестник Кемеровского государственного университета. Серия: гуманитарные и общественные науки
The categories of the direct and the indirect can be classified as paired. The author applied standard and interdisciplinary research methods to the direct and the indirect as criminalistic categories. The article is a review that investigates the direct
Grigory S. Garbouz
doaj   +1 more source

RISIKO GANGGUAN PENDENGARAN PADA NEONATUS HIPERBILIRUBINEMIA [PDF]

, 2010
Background. The prevalence of hearing impairment on the Indonesian population according to 2007 WHO data is estimated at 4.2 %, and one of the cause is neonatal hyperbilirubinemia.
Susanto, Susanto
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Breakup of loosely bound nuclei as indirect method in nuclear astrophysics: 8B, 9C, 23Al

, 2005
We discuss the use of one-nucleon breakup reactions of loosely bound nuclei at intermediate energies as an indirect method in nuclear astrophysics. These are peripheral processes, therefore we can extract asymptotic normalization coefficients (ANC) from ...
Azhari, Bahcall, Beaumel, Beiner, Bertulani, Blank, C. A. Gagliardi, Caggiano, Cai, Cortina-Gil, Cyburt, Davids, Diehl, Enders, Esbensen, F. Carstoiu, Gomi, Hammache, Hansen, Iyundin, Jeukenne, Jose, Junghans, L. Trache, Maddalena, Motobayashi, Mukhamedzhanov, Negoita, R. E. Tribble, Ray, Sauvan, Schumann, Starrfield, Strieder, Tabacaru, Tanihata, Trache, Trache, Trache, Trache, Wanajo, Wiescher, Wiescher, Zhang   +43 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

An update to reflimR: strengthening transparent reference interval verification

Journal of Laboratory Medicine
There are currently two publicly available R packages for the indirect determination of reference intervals: reflimR and refineR. We aimed to optimize the reflimR algorithm to achieve greater concordance with refineR, including in challenging data sets.
Klawitter Sandra, Trulson Inga, Hoffmann Georg   +2 more
doaj   +1 more source

The Pathology of Insistence on Indirect Disclosure of Operating Cash Flows [PDF]

Pizhūhish/hā-yi ḥisābdārī-i mālī
This study examines the gap between investors' and financial managers' views on the presentation of operating cash flows. The method used is three separate surveys conducted through structured questionnaires on random samples of private investors (384 ...
Esmail Farzaneh Kargar, Mehdi Bahar Moghadam   +1 more
doaj   +1 more source