Results 31 to 40 of about 1,151,098 (154)

The Background of Mitochondrial DNA Haplogroup J Increases the Sensitivity of Leber's Hereditary Optic Neuropathy Cells to 2,5-Hexanedione Toxicity [PDF]

, 2009
Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point mutations in complex I subunit genes, whose incomplete penetrance has been attributed to both genetic and environmental factors ...
Achilli Alessandro, GHELLI, ANNA MARIA, Mattioli Stefano, Pala M., Barbieri, Anna, Vidoni S., Torroni Antonio, Carelli Valerio, Anna Barbieri, Vidoni, Sara, Valerio Carelli, Carelli, Valerio, Ghelli, Anna, Mattioli, Stefano, Torroni, Antonio, Iommarini, Luisa, Zanna, Claudia, Pala, Maria, Vidoni Sara, Stefano Mattioli, Antonio Torroni, Achilli A., ZANNA C, Porcelli Anna Maria, Zanna Claudia, Pala Maria, MATTIOLI S, Luisa Iommarini, GHELLI A, Achilli, Alessandro, IOMMARINI L, Rugolo, Michela, Torroni A., Porcelli, Anna Maria, CARELLI V., Ghelli Anna, Rugolo Michela, BARBIERI A, RUGOLO M, PORCELLI AM, Anna Ghelli, Barbieri Anna, Sara Vidoni, Maria Pala, Alessandro Achilli, Anna Maria Porcelli, Michela Rugolo, Claudia Zanna, Iommarini Luisa, VIDONI S   +49 more
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Indirect Traumatic Optic Neuropathy – Two Case Report [PDF]

, 2001
The aim of the study was to evaluate the treatment of indirect traumatic optic neuropathy (ITON). ITON is defined as traumatic loss of vision that occurs without external or initial ophthalmoscopic evidence of injury to the eye or its nerve.
B. Gračner, M. Kovačić, Gračner, B., Kovačić, M., Gračner, T., T. Gračner   +5 more
core   +1 more source

Traumatic Optic Neuropathy – A Conundrum [PDF]

Journal of Clinical and Diagnostic Research, 2016
Visual impairment following head injury may be an enigma especially if the onset of symptoms were to be few days after the actual trauma and the bias arising out of the initial normal ophthalmological examination is not neutralised by unbiased repeated ...
VINOTH KANNA SELVARAJ, RAMACHANDRAN VISWANATHAN, VASUDEVAN DEVANATHAN   +2 more
doaj   +1 more source

Diffusion basis spectrum imaging detects subclinical traumatic optic neuropathy in a closed-head impact mouse model of traumatic brain injury

Frontiers in Neurology, 2023
IntroductionTraumatic optic neuropathy (TON) is the optic nerve injury secondary to brain trauma leading to visual impairment and vision loss. Current clinical visual function assessments often fail to detect TON due to slow disease progression and ...
Hsin-Chieh Yang, Raj Swaroop Lavadi, Andrew D. Sauerbeck, Andrew D. Sauerbeck, Michael Wallendorf, Terrance T. Kummer, Terrance T. Kummer, Terrance T. Kummer, Sheng-Kwei Song, Sheng-Kwei Song, Tsen-Hsuan Lin   +10 more
doaj   +1 more source

Progression and Pathology of Traumatic Optic Neuropathy From Repeated Primary Blast Exposure

Frontiers in Neuroscience, 2019
Indirect traumatic optic neuropathy (ITON) is a condition that is often associated with traumatic brain injury and can result in significant vision loss due to degeneration of retinal ganglion cell (RGC) axons at the time of injury or within the ensuing ...
Alexandra Bernardo-Colón, Victoria Vest, Melissa L. Cooper, Sarah A. Naguib, David J. Calkins, David J. Calkins, Tonia S. Rex, Tonia S. Rex   +7 more
doaj   +1 more source

Clinical profile and visual outcome in patients with traumatic optic neuropathy

Indian Journal of Ophthalmology, 2023
Purpose: To analyze the visual outcome in patients with traumatic optic neuropathy (TON) with respect to different treatment modalities, to study the correlation of initial visual loss with the final visual outcome, and to find out the predictor of final
H Sujithra, Kannisha Shah, C Greeshma
doaj   +1 more source

Traumatic Optic Neuropathy: Early Detection and Intervention in a Tertiary Care Centre [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Acute injury to the optic nerve resulting in vision loss is known as Traumatic Optic Neuropathy (TON). Optical Coherence Tomography (OCT) documents the progression of damage of axons over time.
Arino John, Andrews CV Kakkanatt, Monsy Thomas Mathai, Babu Urumeese Palatty, NI Kurian, Aiswarya Sasidharan   +5 more
doaj   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Intravitreal Injection of Long-Acting Pegylated Granulocyte Colony-Stimulating Factor Provides Neuroprotective Effects via Antioxidant Response in a Rat Model of Traumatic Optic Neuropathy

Antioxidants, 2021
Traumatic optic neuropathy (TON) may cause severe visual loss following direct or indirect head trauma which may result in optic nerve injuries and therefore contribute to the subsequent loss of retinal ganglion cells by inflammatory mediators and ...
Chin-Te Huang, Yao-Tseng Wen, Tushar Dnyaneshwar Desai, Rong-Kung Tsai   +3 more
doaj   +1 more source

Progressive auditory neuropathy in patients with Leber's hereditary optic neuropathy [PDF]

, 2004
Objective: To investigate auditory neural involvement in patients with Leber's hereditary optic neuropathy (LHON).Methods: Auditory assessment was undertaken in two patients with LHON.
Luxon, LM, Ceranic, B
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