Results 101 to 110 of about 13,763,316 (290)

Flowchart of the indirect comparison analysis.

, 2016
Flowchart of the indirect comparison analysis.
Geraldine Reilly (2795326), Josep M. Llibre (199625), Felipe Rogatto (2795323), Georg Behrens (128738), François Raffi (4923), David Piontkowsky (2795320), Stephane Bouee (2795335), Peter Borg (2795329), Graeme Moyle (2795332)   +8 more
core   +1 more source

Bayesian mixed treatment comparison of early treatment for Parkinson disease: an indirect comparison [PDF]

Value in Health, 2015
Marquez, M., Diaz, J.P., Ibarra, A., Pizarro, M., Cervantes, A., Rodríguez, M., Soto, H.   +6 more
openaire   +2 more sources

Comparing the efficacy of cipaglucosidase alfa plus miglustat with other enzyme replacement therapies for late-onset Pompe disease: a network meta-analysis utilizing patient-level and aggregate data

Journal of Comparative Effectiveness Research
Aim: Late-onset Pompe disease is characterized by progressive loss of muscular and respiratory function. Until recently, standard of care was enzyme replacement therapy (ERT) with alglucosidase alfa.
Simon Shohet, Noemi Hummel, Shuai Fu, Ian Keyzor, Alasdair MacCulloch, Neil Johnson, Jeff Castelli, Ilona Czarny-Ozga, Tahseen Mozaffar, Howard Thom   +9 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Indirect treatment comparisons find enhanced effectiveness of pegcetacoplan versus crovalimab in both complement inhibitor-naive and -experienced patients with paroxysmal nocturnal hemoglobinuria

Journal of Comparative Effectiveness Research
Aim: Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare hematological condition, which if undertreated, is associated with significant morbidity and early mortality.
Raymond Siu Ming Wong, Koo Wilson, Zalmai Hakimi, Mikolaj Parkitny, Piotr Wojciechowski, Catherine Flynn, Francis Fatoye   +6 more
doaj   +1 more source

Pegcetacoplan Versus Iptacopan for the Treatment of Patients with C3 Glomerulopathy: Indirect Treatment Comparisons

Advances in Therapy
C3 glomerulopathy (C3G) is a rare complement-mediated kidney disease. Pegcetacoplan [targeted complement 3 (C3)/C3b inhibitor] and iptacopan (factor B inhibitor) target the complement system and are approved for treatment of C3G in adults and adolescents (pegcetacoplan) or adults only (iptacopan). Currently, no head-to-head randomized controlled trials
Bradley P. Dixon, Andrew S. Bomback, Carly Rich, Zalmai Hakimi, Mingyi Huang, Kathryn Gordon, Piotr Wojciechowski, Wojciech Margas, Rose Chang, Mei Sheng Duh, Fernando Caravaca-Fontán, Fadi Fakhouri   +11 more
openaire   +3 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Indirect treatment comparisons: how to MAIC it right?

Haematologica
Not available.
openaire   +4 more sources

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Direct and indirect comparison meta-analysis of levetiracetam versus phenytoin or valproate for convulsive status epilepticus

, 2016
The aim of this study was to conduct a meta-analysis of published studies to directly compare intravenous (IV) levetiracetam (LEV) with IV phenytoin (PHT) or IV valproate (VPA) as second-line treatment of status epilepticus (SE), to indirectly compare ...
Nardone, Raffaele, Trinka, Eugen, Bragazzi, Nicola, BRIGO, Francesco   +3 more
core   +1 more source