Results 81 to 90 of about 13,763,316 (290)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints [PDF]

, 2015
In an adaptive seamless phase II/III clinical trial interim analysis data are used for treatment selection, enabling resources to be focussed on comparison of more effective treatment(s) with a control.
Friede, Tim, Parsons, Nicholas, Parsons, Nicholas R., Kunz, Cornelia, Todd, Susan, Kunz, Cornelia Ursula, Stallard, Nigel   +6 more
core   +1 more source

A consensus guide to preclinical indirect calorimetry experiments

Understanding the complex factors influencing mammalian metabolism and body weight homeostasis is a long-standing challenge requiring knowledge of energy intake, absorption and expenditure.
Tiganis, Tony, James, David E, Heymsfield, Steven B., Thyfault, John P, Auwerx, Johan, Hevener, Andrea L., Allison, David B., Ward, Christopher S., Austad, Steven N, Wolfrum, Christian, Gerhart-Hines, Zachary, Xu, Ying, Ansarullah, de Cabo, Rafael, Medina‐Gómez, Gema, Selloum, Mohammed, Scherer, Philipp E, \u160kop, Vojt\u11bch, Grobe, Justin L, Speakman, John R, Spiegelman, Bruce M., Habegger, Kirk M., Ayala, Julio E, Alquier, T, Reitman, Marc L, Ayala, JE, Titchenell, Paul M., Škop, Vojtěch, Ferrante, Anthony W., Speakman, John R., Shulman, Gerald I., Baur, Joseph A, Lo, James C., MacLean, Paul S, Steinberg, Gregory R., Hartig, Sean M, Rensen, Patrick C N, Churchill, Gary A., Allison, DB, Banks, Alexander S, de Angelis, Martin Hrabě, Williams, Ashley S., Gupta, Rana K., Ansarullah,, Lodhi, Irfan J., Klingenspor, Martin, Chen, Shuai, Auwerx, J, Kooijman, Sander, Mirmira, Raghavendra G, Grobe, Justin L., Williams, Ashley S, Banks, AS, Carobbio, Stefania, Finck, Brian N., Steinberg, Gregory R, Donato, Jose, Rutkowsky, Jennifer M, M\ufcller, Timo D., Banks, Alexander S.;Allison, David B.;Alquier, Thierry;Ansarullah;Austad, Steven N.;Auwerx, Johan;Ayala, Julio E.;Baur, Joseph A.;Carobbio, Stefania;Churchill, Gary A.;Dall, Morten;de Cabo, Rafael;Donato, Jose, Jr.;Dragano, Nathalia R. V.;Elias, Carol F.;Ferrante, Anthony W., Jr.;Finck, Brian N.;Galgani, Jose E.;Gerhart-Hines, Zachary;Goodyear, Laurie J.;Grobe, Justin L.;Gupta, Rana K.;Habegger, Kirk M.;Hartig, Sean M.;Hevener, Andrea L.;Heymsfield, Steven B.;Holman, Corey D.;de Angelis, Martin Hrabě;James, David E.;Kazak, Lawrence;Kim, Jae Bum;Klingenspor, Martin;Kong, Xingxing;Kooijman, Sander;Lantier, Louise;Lloyd, K. C. Kent;Lo, James C.;Lodhi, Irfan J.;MacLean, Paul S.;McGuinness, Owen P.;Medina-Gómez, Gema;Mirmira, Raghavendra G.;Morrison, Christopher D.;Morton, Gregory J.;Müller, Timo D.;Ogawa, Yoshihiro;Pajuelo-Reguera, David;Potthoff, Matthew J.;Qi, Nathan;Reitman, Marc L.;Rensen, Patrick C. N.;Rozman, Jan;Rutkowsky, Jennifer M.;Sakamoto, Kei;Scherer, Philipp E.;Schwartz, Gary J.;Sedlacek, Radislav;S, Ward, Christopher S, Sedlacek, Radislav, Elias, Carol F, Rensen, Patrick C.N., Soukas, Alexander A, Ward, Christopher, Velloso, Licio A, Allison, David B, Dall, M, Morrison, Christopher D, Müller, Timo D., Elias, Carol F., MacLean, Paul S., de Angelis, Martin Hrab\u11b, Müller, Timo D, Dall, Morten, Potthoff, Matthew J, Vidal-Puig, Antonio, Ferrante, Anthony W, Banks, Alexander S., Rozman, Jan, Morton, Gregory J., Xu, Allison W., Ogawa, Yoshihiro, Reguera, David Pajuelo, Baur, JA, Holman, Corey D., Kazak, Lawrence, McGuinness, Owen P, Reitman, Marc L., Churchill, GA, Hevener, Andrea L, Hartig, Sean M., Velloso, Lı́cio A., Thyfault, John P., Austad, Steven N., Ayala, Julio E., Vidal‐Puig, Antonio, Zierath, Juleen R, Svensson, Katrin J., Mirmira, Raghavendra G., Carobbio, S, Alquier, Thierry, The International Indirect Calorimetry Consensus Committee (IICCC, Galgani, José E., Churchill, Gary, Potthoff, Matthew J., Morton, Gregory J, Shulman, Gerald I, Spiegelman, Bruce M, Morrison, Christopher D., Dragano, Nathalia R. V., Lodhi, Irfan J, Sakamoto, Kei, Scherer, Philipp E., Gupta, Rana K, Qi, Nathan, Turner, Nigel, Medina-G\uf3mez, Gema, Rensen, Patrick C. N., Velloso, Licio A., Zierath, Juleen R., Dragano, Nathalia Romanelli Vicente, McGuinness, Owen P., Schwartz, Gary J., Goodyear, Laurie J., Kong, Xingxing, Kim, Jae Bum, Holman, Corey D, Rutkowsky, Jennifer M., Shaikh, Saame Raza, Svensson, Katrin J, Xu, Allison, Medina-Gómez, Gema, Gerhart‐Hines, Zachary, Austad, SN, Goodyear, Laurie J, Habegger, Kirk M, Galgani, Jose E, Churchill, Gary A, Pajuelo-Reguera, David, Lantier, Louise, Finck, Brian N, James, David E., Baur, Joseph A., International Indirect Calorimetry Consensus Committee (IICCC), Dragano, Nathalia R V, Schwartz, Gary J, Heymsfield, Steven B, Lo, James C, Lloyd, K C Kent, Soukas, Alexander A., Xu, Allison W, Lloyd, K. C. Kent, Titchenell, Paul M   +154 more
core   +2 more sources

Indirect treatment comparison of bevacizumab + interferon-α-2a vs tyrosine kinase inhibitors in first-line metastatic renal cell carcinoma therapy

ClinicoEconomics and Outcomes Research, 2011
Gerald HJ Mickisch1, Björn Schwander2, Bernard Escudier3, Joaquim Bellmunt4, José P Maroto5, Camillo Porta6, Stefan Walzer7, Uwe Siebert8,91Department of Urology, Center of Operative Urology Bremen, Bremen, Germany; 2Department of ...
Gerald HJ Mickisch, Björn Schwander, Bernard Escudier, et al   +3 more
doaj  

Advanced Therapy Medicinal Products (ATMP)and exemptions to the Regulation 1394/2007: how confident can we be? An exploratory analysis.

Frontiers in Pharmacology, 2012
The market authorisation procedure for medicinal products for human use is relying on their demonstrated efficacy, safety and pharmaceutical quality. This applies to all medicinal products whether of chemical or biological origin. Since October 2009, the
Philippe eVan Wilder
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Comparative Performance And Clinical Utility Of Indirect Treatment Comparison Estimators [PDF]

, 2017
In the clinical decision between two or more discrete competing diagnostic or therapeutic patient care strategies, the main consideration is typically the expected difference in the primary outcome of interest.
Hillegass, William
core  

Network connectivity, between-study heterogeneity and timepoint challenges in generalized myasthenia gravis: a feasibility assessment of indirect treatment comparisons

Journal of Comparative Effectiveness Research
Aim: We performed a feasibility assessment to systematically evaluate randomized controlled trials (RCTs) for generalized myasthenia gravis (gMG) treatments.
Nils Erik Gilhus, Saiju Jacob, Mahmoud Hashim, Suzy Van Sanden, Christopher Drudge, Anna Nero, Sumeet Singh, Kavita Gandhi, Brian Hutton   +8 more
doaj   +1 more source