Results 61 to 70 of about 13,763,316 (290)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Hazard ratios (HR) and 95% Confidence Interval (CI) for overall survival (OS) for studies included in the indirect treatment comparison for cabazitaxel, abiraterone acetate and enzalutamide.

, 2018
Hazard ratios (HR) and 95% Confidence Interval (CI) for overall survival (OS) for studies included in the indirect treatment comparison for cabazitaxel, abiraterone acetate and enzalutamide.
Jackie Vanderpuye-Orgle (5089457), Lindsay Townes (5089460), Heidi Reichert (5089463), Nicholas Summers (4102141), Jon P. Fryzek (5089454), Robert Deuson (5089451), Dominik D. Alexander (704966)   +6 more
core   +1 more source

How does risdiplam compare with other treatments for Types 1-3 spinal muscular atrophy: a systematic literature review and indirect treatment comparison

, 2022
Aim: To conduct indirect treatment comparisons between risdiplam and other approved treatments for spinal muscular atrophy (SMA). Patients & methods: Individual patient data from risdiplam trials were compared with aggregated data from published ...
Evans, Rachel, Scott, David Alexander, Mahajan, Anadi, Daigl, Monica, Gorni, Ksenija, Hawkins, Neil, Martí, Yasmina, Abrams, Keith R, Ribero, Valerie Aponte, Yasmina Martí, Rachel Evans, David Alexander Scott, Ksenija Gorni, Anadi Mahajan, Keith R Abrams, Monica Daigl, Valerie Aponte Ribero, Neil Hawkins   +17 more
core   +1 more source

Nemolizumab Versus Dupilumab in the Treatment of Prurigo Nodularis: Systematic Literature Review and Network Meta-analysis

Dermatology and Therapy
Prurigo nodularis (PN) is a chronic skin condition characterized by severe, persistent pruritus and impairment in health-related quality of life. Dupilumab and nemolizumab are the only treatments approved by the US Food and Drug Administration and the ...
Gil Yosipovitch, Katarzyna Borkowska, James Frampton, Kassandra Schaible, Marissa Betts, Katrin Jack, Zarif Jabbar Lopez, Binod Neupane, Christophe Piketty, Ramkumar Subramanian, Jorge Puelles Fernández de Trocóniz   +10 more
doaj   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Methodological review of NMA bias concepts provides groundwork for the development of a list of concepts for potential inclusion in a new risk of bias tool for network meta-analysis (RoB NMA Tool)

Systematic Reviews
Introduction Network meta-analyses (NMAs) have gained popularity and grown in number due to their ability to provide estimates of the comparative effectiveness of multiple treatments for the same condition.
Carole Lunny, Areti-angeliki Veroniki, Julian P. T. Higgins, Sofia Dias, Brian Hutton, James M. Wright, Ian R. White, Penny Whiting, Andrea C. Tricco   +8 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Hazard ratios (HR) and 95% Confidence Interval (CI) for progression-free survival (PFS) for studies included in the indirect treatment comparison for cabazitaxel, abiraterone acetate and enzalutamide.

, 2018
Hazard ratios (HR) and 95% Confidence Interval (CI) for progression-free survival (PFS) for studies included in the indirect treatment comparison for cabazitaxel, abiraterone acetate and enzalutamide.
Jackie Vanderpuye-Orgle (5089457), Lindsay Townes (5089460), Heidi Reichert (5089463), Nicholas Summers (4102141), Jon P. Fryzek (5089454), Robert Deuson (5089451), Dominik D. Alexander (704966)   +6 more
core   +1 more source

Overall survival of glasdegib in combination with low-dose cytarabine, azacitidine, and decitabine among adult patients with previously untreated AML: comparative effectiveness using simulated treatment comparisons

ClinicoEconomics and Outcomes Research, 2019
Gabriel Tremblay1, Tracy Westley1, Joseph C Cappelleri2, Bhakti Arondekar2, Geoffrey Chan2, Timothy J Bell2, Andrew Briggs3 1Purple Squirrel Economics, New York, NY, USA; 2Pfizer Inc, New York, NY, USA; 3William R Lindsay Chair of Health Economics ...
Tremblay G, Westley T, Cappelleri JC, Arondekar B, Chan G, Bell TJ, Briggs A   +6 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source