Results 91 to 100 of about 3,427 (196)

Pinpointing top inhibitors for GSK3β from pool of indirubin derivatives using rigorous computational workflow and their validation using molecular dynamics (MD) simulations

Scientific Reports
Glycogen synthase kinase-3β (GSK3β) is a pivotal protein kinase implicated in a spectrum of debilitating diseases, encompassing cancer, diabetes, and neurodegenerative disorders.
Vamangi Pandya, Priyashi Rao, Jignesh Prajapati, Rakesh M. Rawal, Dweipayan Goswami   +4 more
doaj   +1 more source

Meisoindigo, but not its core chemical structure indirubin, inhibits zebrafish interstitial leukocyte chemotactic migration

Pharmaceutical Biology, 2017
Context: Inflammatory disease is a big threat to human health. Leukocyte chemotactic migration is required for efficient inflammatory response. Inhibition of leukocyte chemotactic migration to the inflammatory site has been shown to provide therapeutic ...
Baixin Ye, Xiaoxing Xiong, Xu Deng, Lijuan Gu, Qiongyu Wang, Zhi Zeng, Xiang Gao, Qingping Gao, Yueying Wang   +8 more
doaj   +1 more source

Bromine indirubin FLIM/PLIM sensors to measure oxygen in normoxic and hypoxic PDT conditions

Photodiagnosis and Photodynamic Therapy
Background: The induction of phototoxicity during photodynamic therapy (PDT) is dependent on oxygen availability. For this reason, the development of sensors to measure oxygen and oxygen consumption is extremely important.
D.N.S. dos Santos, N. Naskar, E. Delgado-Pinar, K. Reess, J.S. Seixas de Melo, A. Rueck   +5 more
doaj   +1 more source

An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

Parasites & Vectors, 2014
Background In search of new antiparasitic agents for overcoming the limitations of current leishmaniasis chemotherapy, we have previously shown that 6-bromoindirubin-3'-oxime (6BIO) and several other 6-substituted analogues of indirubin, a naturally ...
Antonia Efstathiou, Nicolas Gaboriaud-Kolar, Despina Smirlis, Vassilios Myrianthopoulos, Konstantina Vougogiannopoulou, Alexandros Alexandratos, Marina Kritsanida, Emmanuel Mikros, Ketty Soteriadou, Alexios-Leandros Skaltsounis   +9 more
doaj   +1 more source

Detection, Occurrence and Fate of Indirubin in Municipal Sewage Treatment Plants

, 2016
Indirubin which has been isolated from human urine is an extremely potent AhR agonist. This paper first established an analytical method based on liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for indirubin in ...
Ying Zhao (16546), Bin Shao (460997), Hong Chang (187060), Jun Zhou (6477), Jianying Hu (1430806), Shimin Wu (556146), Lezheng Wang (2409004)   +6 more
core   +1 more source

N-Glycosides of indigo, indirubin, and isoindigo: blue, red, and yellow sugars and their cancerostatic activity

Beilstein Journal of Organic Chemistry
Indigo, indirubin, and isoindigo derivatives have been used for centuries as pigments. Since the 1990s, a new aspect of the chemistry of this type of compounds is their activity against various types of cancer.
Peter Langer
doaj   +1 more source

Indirubin inhibits cell proliferation, migration, invasion andangiogenesis in tumor-derived endothelial cells

, 2017
Hepatocellular Carcinoma is one of the most predominant malignancies with high fatality rate and is rising at an alarming rate because it is quite resistant to radioand chemotherapy.
He xinyue, Chen yu, Li zhuohong, Qian Lin, Shijie Li, Zhu chaofu, An baiping, Lan lan   +7 more
core   +1 more source

The combination of indirubin and isatin attenuates dextran sodium sulfate induced ulcerative colitis in mice

, 2018
Indirubin and isatin have been used in the treatment of inflammatory diseases due to their anti-inflammatory properties. This study aimed to evaluate the combined effect of indirubin and isatin on dextran sulfate sodium (DSS)-induced ulcerative colitis (
Li Yu, Yang Gong, Luding Zhang, Wenyan Gao, Xiaoqian Wang, Changhong Wang   +5 more
core   +1 more source

ID:2040 Antileukemic and antiplatelet activities of indirubin-3'-oxime, an active ingredient semi-synthesized from indirubin-rich powder of medicinal plant Strobilanthes cusia (Nees.) O. Kuntze (Acanthaceae)

, 2017
Indirubin-3’-oxime (IOX) is an active ingredient semi-synthesized from indirubin-rich powder produced from medicinal plant Strobilanthes cusia (Nees.) O. Kuntze (Acanthaceae). IOX exhibits antileukemic and antiplatelet activities.
Cuong Nguyen Manh
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source