Results 81 to 90 of about 3,427 (196)
A METHOD FOR THE QUANTITATIVE ESTIMATION OF INDICAN AND INDIRUBIN IN THE URINE. [PDF]
JAMA: The Journal of the American Medical Association, 1898 The methods in general use for the detection of indican in the urine are too well known to require recapitulation; they are qualitative and are of little or no value for clinical diagnosis; all are based on the breaking up of the indoxyl sulphate with hydrochloric acid, oxidizing the indoxyl into indigo, dissolving in chloroform, when the blue ...
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An evaluation of indirubin analogues as phosphorylase kinase inhibitors
Journal of Molecular Graphics and Modelling, 2015 Phosphorylase kinase (PhK) has been linked with a number of conditions such as glycogen storage diseases, psoriasis, type 2 diabetes and more recently, cancer (Camus et al., 2012 [6]). However, with few reported structural studies on PhK inhibitors, this hinders a structure based drug design approach.
Begum, Jaida +8 more
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Indirubin is the main component of the traditional Chinese medicine Indigo naturalis (IN), a potent agonist of aryl hydrocarbon receptors (AhRs). In China, IN is used to treat psoriasis and ulcerative colitis, and indirubin is used for the treatment of ...
Lixin Sun (652460) +8 more
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THE EFFECTS OF INDIRUBIN DERIVITIVES ON GENE EXPRESSION AND CELLULAR FUNCTIONS IN THE MURINE MACROPHAGE [PDF]
, 2008 Indirubin is the active ingredient in the ancient herbal remedy, Danggui Longhui Wan, which is used as an anti-leukemic, anti-inflammatory, and detoxification treatment.
Babcock, Abigail
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Optimization of indirubin and indigo production in E.coli [PDF]
, 2015 The goal of this thesis is to determine the conditions that give the highest yield of indigo and indirubin in recombinant E.coli. This E.coli has been transformed with a P450 gene from woad, an indigo producing plant. The conditions investigated were the
Cairo, Gisela
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Physicochemical characterization and in vitro permeation of an indirubin derivative
European Journal of Pharmaceutical Sciences, 2013 The active component of the traditional Chinese medicine, indirubin, exerts anticancer effect on different cancer cell lines. E804, a potent derivative of indirubin inhibits the activation of Stat3 and Stat5 in chronic myelocytic leukaemia (CML) cells.
Nasim, Heshmati +6 more
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Biologia Plantarum, 2019 Nitrogen and sulfur are major elements influencing plant growth and production of secondary metabolites. They interact to each other, but little is known about it in Isatis indigotica Fort. plants.
Y.J. Miao +8 more
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Study of the Interaction of Indirubin with Bovine Serum Albumin
Chemical and Pharmaceutical Bulletin, 2006 This study examined the interaction of indirubin with bovine serum albumin (BSA) at three temperatures (286, 297, 308 K) at pH 7.40. In the presence of indirubin, the drug-BSA binding mode, binding constant and the protein structure changes in aqueous solution were determined by fluorescence quenching methods including Fourier transform infrared (FT-IR)
Bian, Hedong +5 more
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Molecular Dynamics Mechanisms of the Inhibitory Effects of Abemaciclib, Hymenialdisine, and Indirubin on CDK-6 [PDF]
, 2019 BACKGROUND: Cyclin-Dependent Kinases-6 (CDK-6) is a serine/threonine protein kinase with regular activity in the cell cycle. Some inhibitors, such as abemaciclib, hymenialdisine, and indirubin, cause cell arrest by decreasing its activity.
Basati, G. +9 more
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