Results 61 to 70 of about 3,427 (196)

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

Rapamycin Partially Reverts Cavernoma Endothelial Cell Phenotype and, When Combined With Lapatinib, Ameliorates Chronic Lesions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT This study investigates the impact of rapamycin and propranolol on cerebral cavernous malformations (CCMs). Employing an unbiased transcriptomic analysis, we aimed to comprehensively elucidate the molecular mechanisms underlying these drug effects.
Mar García‐Colomer, José E. Martínez, Luis Díaz‐Gómez, Miriam Sartages, Eva M. Esquinas‐Román, Cristina Riobello, David Martínez‐Delgado, Diego González‐Pérez, Aurora Gómez‐Durán, Miguel Fidalgo, Marta Varela‐Rey, Celia M. Pombo, Juan Zalvide   +12 more
wiley   +1 more source

Darstellung pharmakologisch relevanter Indirubin-N-glykoside und deren Analoga [PDF]

, 2008
Indirubin, das rote Isomer von Indigo, wurde als die aktive Spezies einer Kräutermixtur identifiziert, die in der traditionellen chinesischen Medizin gegen chronisch myeloische Leukämie (CML) eingesetzt wurde. Ausgehend von Anilin bzw. Indolin, konnten N-
Libnow, Stefanie (gnd: 137012144)
core   +1 more source

UHPLC–MS based metabolomics study of the ErZhi formula on skeletal muscle against osteosarcopenia focusing on energy metabolism

Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1235-1247, June 2026.
ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang, Ningning Li, Yujie Ding, Shuzhen Hou, Jing Liu, Xiuxue Liu, Erwei Liu, Xiaopeng Chen   +7 more
wiley   +1 more source

QSAR data of indigo, indirubin, and isoindigotin, including tautomers

, 2021
Quantitative structure-activity relationship (QSAR) data of indigo and the isomers indirubin and isoindigotin, as well as their ...
Bützer, Peter
core   +1 more source

Medicinal Insights Into FLT3 Inhibitors as Anticancer Agents: Current Status and Future Direction

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Structure–activity relationship of FMS‐like tyrosine kinase 3 (FLT3) as potent anti‐cancer agents supported by biological evaluation, in silico and clinical trial studies. ABSTRACT FMS‐like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase (RTK) important for hematopoietic stem cell proliferation, differentiation, and survival.
Ankush Kumar, Pallvi Kumari, Keshav Raj Paudel, Rajwinder Kaur, Rohit Bhatia   +4 more
wiley   +1 more source

Qingdainone, a novel bioactive compound in Realgar‒Indigo naturalis, induced apoptosis and differentiation in ATRA‐sensitive and ‐resistant acute promyelocytic leukaemia cells

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Network pharmacology identified Qingdainone as a key bioactive compound in RIF. 2. Molecular docking revealed strong binding affinities of Qingdainone to targets such as CCND1, CDK1, CDK4, CASP3 and CASP7. 3. Qingdainone interfered proliferation and apoptosis, and promoted differentiation, of ATRA‐sensitive and ‐resistant APL cells, such that ...
Pengcheng Xu, Yang Ou, Xin Tan, Lili Ji, Yanxia Zhan, Pu Chen, Hao Chen, Yunfeng Cheng   +7 more
wiley   +1 more source

Molecular Structures and Spectral Properties of Natural Indigo and Indirubin: Experimental and DFT Studies

Molecules, 2019
This paper presents a comparative study on natural indigo and indirubin in terms of molecular structures and spectral properties by using both computational and experimental methods.
Zixin Ju, Jie Sun, Yanping Liu
doaj   +1 more source

Purple Urine Bag Syndrome [PDF]

Journal of Clinical and Diagnostic Research, 2015
Purple urine bag syndrome (PUBS) is a rare disorder seen in elderly persons, wherein the urinary bag and the tubing turn in to purple colour. It is usually seen in patients who are on urinary catheters for a long time.
NAUFAL RIZWAN TARAGANAR ABUBACKER, SENTHIL MANIKANDAN THIRUMANILAYUR JAYARAMAN, KANNAN R, MAGESH KUMAR SIVANESAN, RENU MATHEW   +4 more
doaj   +1 more source

Thermally Bistable Stiff Stilbene Photoswitches and Polymer Applications

The Chemical Record, Volume 26, Issue 6, June 2026.
Thermally stable photoswitches offer new opportunities for controlling polymer structures and functions under nonequilibrium conditions. This Personal Account highlights stiff stilbene (SS) and sterically hindered stiff stilbene (HSS) photoswitches, which combine large structural changes with exceptional thermal bistability.
Keiichi Imato
wiley   +1 more source