Results 51 to 60 of about 3,427 (196)
Journal of Applied Toxicology, Volume 46, Issue 10, Page 3498-3505, October 2026.ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley +1 more source
Spectroscopic techniques and insilico evaluation of indirubin
, 2020 This thesis was written by Priyanshu Bharadwaj of Birla Institute of Technology Mesra and incorporates the use of curcumin and indirubin for Hidradenitis suppurativa and for rheumatoid ...
Priyanshu Bharadwaj (8458161)
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MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
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Antitumor activity of novel indirubin derivatives in rat tumor model
, 2007 Purpose: The novel indirubin derivatives 5'-nitro-indirubinoxime, 5'-fluoro-indirubinoxime, and 5'-trimethylacetamino-indirubinoxime were designed and tested for antitumor activity both in vitro and in vivo using rat tumor model ...
Min, Jung-Joon +6 more
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Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases.
Damiens E +13 more
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Cytotoxic activity of Isatis campylocarpa, an Iranian endemic plant, on human cancer cell lines [PDF]
Journal of Cell and Molecular Research, 2009 The antineoplastic activities of alcoholic and aqueous extracts of the roots, stems and leaves of Isatis campylocarpa an endemic species of the Brassicaceae family from Iran, investigated on the growth of Jurkat as an acute lymphocytic leukemia cell line,
Sasan Mohsenzadeh +3 more
doaj +1 more source
Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential
Biomolecules, 2021 Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin +4 more
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Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis
Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala +2 more
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Inhibitory Effects of Indirubin Derivatives on the Growth of HL-60 Leukemia Cells
Natural Product Communications, 2010 Six indirubin derivatives have been synthesized and their inhibitory effects on the growth of HL-60 human promyelocytic leukemia cells investigated. Cell viability was determined using the trypan blue exclusion method.
Nguyen Manh Cuong +6 more
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Molecules, 2017 Indirubin is an active component of the herbal ingredient ‘Danggui Longhui wan’, which was used for the treatment of inflammation and chronic myeloid leukemia in China.
Jana Tegethoff +5 more
doaj +1 more source