Results 71 to 80 of about 3,427 (196)

Tapinarof as a Therapeutic Aryl Hydrocarbon Receptor‐Modulating Agent in the Treatment of Atopic Dermatitis

The Journal of Dermatology, Volume 53, Issue 6, Page 867-879, June 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory dermatitis underpinned by Type 2 inflammation driven by cytokines such as IL‐4 and IL‐13. It is characterized by skin barrier dysfunction, Th2 immune deviation, and pruritus. While biologics and oral Janus kinase (JAK) inhibitors demonstrate high therapeutic efficacy by targeting cytokines that ...
Gaku Tsuji, Yoko Fuyuno, Koji Kawamura, Ayako Yumine, Masaki Takemura, Yasutaka Mitamura, Kazuhiko Yamamura, Takeshi Nakahara   +7 more
wiley   +1 more source

Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda, Renu Khasa, Srinivasan Chinnapaiyan, Saurabh Aggarwal, Irfan Rahman, Hoshang Unwalla   +5 more
wiley   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Cytometrical analysis of the adverse effects of indican, indoxyl, indigo, and indirubin on rat thymic lymphocytes [PDF]

, 2018
Many businesses thrive by producing health supplements from agricultural products, as exemplified by the production of functional (or health) food using plants traditionally cultivated in the rural areas.
アズマ, アヤコ, Funakoshi, Yurie, イシカワ, ミヅキ, 平井, 松午, 20156631, 1018, Oyama, Yasuo, 1079, 60529/profile-ja.html, オヤマ, ヤスオ, タムラ, ヤスアキ, フナコシ, ユリエ, カネマル, カヲリ, ヒライ, ショウゴ, 小山, 保夫, イツキ, サトル, Hirai, Shogo, 1032, 00243676, Ishikawa, Mizuki, Tamura, Yasuaki, Itsuki, Satoru, 80214229, 金丸, 芳, Azuma, Ayako, Kanemaru, Kaori   +25 more
core  

Rapid and Integrated Quality Assessment of Organic-Inorganic Composite Herbs by FTIR Spectroscopy—Global Chemical Fingerprints Identification and Multiple Marker Components Quantification of Indigo Naturalis (Qing Dai)

Molecules, 2018
This research aimed to develop an FTIR-based method for rapid and low-cost integrated quality assessment of organic-inorganic composite herbs, which are kinds of herbs composed of both organic and inorganic active ingredients or matrix components.
Meng Pan, Wenxuan Pei, Yixin Yao, Ling Dong, Jianbo Chen   +4 more
doaj   +1 more source

Comprehensive Evaluation of Fructus Tsaoko, Seeds of Tsaoko Fructus and Ginger Made Seeds of Tsaoko Fructus Based on Drug‐Like Compounds and Aroma Analysis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This study mainly consists of two parts. First, after screening for drug‐like metabolites via LC–MS and GC–MS, a comprehensive evaluation model was established using a principal component analysis‐based weighted scoring method, by which the drug‐likeness ranking of three samples was determined.
Han Chen, Meiquan Yang, Weize Yang, Mingju Qi, Zongliang Xu, Tianmei Yang, Jinyu Zhang   +6 more
wiley   +1 more source

Biocatalytic Indigo Synthesis From L‐Tryptophan Using a Three‐Step Cascade Without Cofactor Regeneration

ChemBioChem, Volume 27, Issue 8, April 2026.
A self‐sufficient, NAD(P)H‐independent enzyme cascade for the synthesis of indigo from L‐tryptophan. The minimal cascade uses pyruvate, a byproduct of tryptophan cleavage, to generate hydrogen peroxide, which fuels the key hydroxylation of indole to indoxyl by an engineered tyrosine hydroxylase.
Vivian P. Willers, Nikola Lončar, Marco W. Fraaije   +2 more
wiley   +1 more source

Purple urine bag syndrome

Journal of Family Medicine and Primary Care, 2013
Purple urine bag syndrome (PUBS) is rare disease entity, occurs predominantly in constipated women, chronically catheterized and associated with bacterial urinary infections that produce sulphatase/phosphatase.
Ahmed Al Montasir, Ahmed Al Mustaque
doaj   +1 more source

Ueber das Indigoroth (Indirubin) [PDF]

Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin, 1891
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openaire   +1 more source

Analysis and prediction of immune cell infiltration characteristics in COPD: Folium isatidis and its active ingredients are able to combat lung lesions caused by COPD by correcting immune cell infiltration

Frontiers in Medicine
ObjectiveAs a respiratory disease, chronic obstructive pulmonary disease (COPD) has become a common fatal disease worldwide. We aimed to screen active traditional Chinese medicines (TCMs) for the treatment of COPD by COPD-related transcriptome gene chip ...
Faqin Wang, Faqin Wang, Weichen Zhang, Yujie Huang, Xianbang Hou, Liwei He, Liwei He, Huiqin Xu   +7 more
doaj   +1 more source