Results 231 to 240 of about 4,923,442 (291)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Erratum: Malocclusion: An adjunctive aid in individual identification.

J Oral Maxillofac Pathol, 2020
europepmc   +1 more source

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Checkwriter Identification—Individuality

Journal of Forensic Sciences, 1982
Abstract Checkwriters are established machines in the contemporary business world and, as such, are an established vehicle of criminal action. This paper offers practical suggestions for the identification of checkwriters through their impressions from information gained through original research.
TW Vastrick, EJ Smith
openaire   +1 more source

NATIONAL INDIVIDUAL IDENTIFICATION OF HORSES

Australian Veterinary Journal, 1977
Methods of equine identification including signalment, blood typlng, tattooing and freeze marking are discussed. A new system of individually identifying horses with an unalterable freeze mark is proposed. Unalterable numerical and alphabetical symbols have been developed to apply a registration number to the animal.
R K, Farrell, B J, Hilbert
openaire   +2 more sources

ECG to Individual Identification

2008 IEEE Second International Conference on Biometrics: Theory, Applications and Systems, 2008
This paper presents an individual identification system using single lead electrocardiogram (ECG). The proposed techniques for P and T wave delineation are based on time derivative and adaptive thresholding. The performance of proposed delineators is evaluated on manually annotated Physionet QT database.
Yogendra Narain Singh, Phalguni Gupta
openaire   +1 more source

SNPs for individual identification

Forensic Science International: Genetics Supplement Series, 2008
Abstract Using population genetics criteria for SNPs for individual identification (IISNPs) – SNPs having nearly maximum informativeness in populations from all parts of the world – on a reduced screening panel of 31 populations, those most likely to be forensically relevant, we have identified a panel of 108 candidate SNPs that meet our ...
A.J. Pakstis, W.C. Speed, J.R. Kidd, K.K. Kidd   +3 more
openaire   +1 more source

Molecular Identification of Individual Nano-Objects

Analytical Chemistry, 2009
Secondary ion mass spectrometry (SIMS) run in the event-by-event bombardment/detection mode provides a unique ability to obtain molecular information from single nano-objects, since assays are based on secondary ion coemission from single impacts. The characterization of individual nano-objects is demonstrated with negatively charged polymer spheres ...
Veronica T, Pinnick, Stanislav V, Verkhoturov, Leonid, Kaledin, Yordanos, Bisrat, Emile A, Schweikert   +4 more
openaire   +2 more sources