Results 91 to 100 of about 256,812 (272)

Social firms as a means of vocational recovery for people with mental illness : a UK survey [PDF]

, 2013
Background: Employment is associated with better quality of life and wellbeing in people with mental illness. Unemployment is associated with greater levels of psychological illness and is viewed as a core part of the social exclusion faced by people ...
Marwaha, Steven, Morant, Nicola, Marwaha, S, Parsons, Nicholas, Parsons, Nicholas R., Morant, N, Eleanor Gilbert, Swaran Singh, Nicholas Parsons, Johnson, Sonia, Milton, A, Nicola Morant, Milton, Alyssa, Gilbert, E., Singh, Swaran, Johnson, S, Gilbert, E, Singh, S, Fisher, Adrian, Di Cunliffe, Gilbert, Eleanor, Fisher, A., Steven Marwaha, Sonia Johnson, Singh, Swaran P., Fisher, A, Alyssa Milton, Marwaha, Steven; id_orcid, Parsons, N, Adrian Fisher, Cunliffe, D, Cunliffe, Di   +31 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Supported employment for persons with mental illness: Systematic review of the effectiveness of individual placement and support in the UK [PDF]

, 2011
Background. High levels of unemployment among persons with mental illness are a significant social disability. The individual placement and support (IPS) model of vocational support has been shown to be effective in establishing persons with mental ...
Pilkington, Paul, John Heffernan, Heffernan, John, Paul Pilkington   +3 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

“I've actually surprised myself at what I can do”: Understanding the longer-term experiences of individual placement and support (IPS) embedded within primary healthcare

SSM - Mental Health
Background: Persons with persistent and multiple barriers (PPMB), including mental health and substance use (MHSU) and other disabilities, often experience inequitable challenges obtaining and sustaining competitive employment opportunities.
Amanda Kwan, Padmini Thakore, Madelyn Whyte, Taite Beggs, Stephany Berinstein, Jonathan Morris, Skye Barbic   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Good psychiatric management for borderline personality disorder: A qualitative study of its implementation in a supported employment team.

PLoS ONE
IntroductionPeople with borderline personality disorder have difficulties with work. The Individual Placement and Support model has shown its worldwide effectiveness in terms of vocational rehabilitation for individuals with psychiatric disorders ...
Noëllie Dunand, Philippe Golay, Charles Bonsack, Danièle Spagnoli, Valentino Pomini   +4 more
doaj   +1 more source

Protocol for the SEED-trial: Supported Employment and preventing Early Disability

BMC Public Health, 2016
Background Early withdrawal or exclusion from the labor market leads to significant personal and societal costs. In Norway, the increasing numbers of young adults receiving disability pension is a growing problem.
Vigdis Sveinsdottir, Torill Helene Tveito, Gary R. Bond, Astrid Louise Grasdal, Stein Atle Lie, Silje Endresen Reme   +5 more
doaj   +1 more source