Results 71 to 80 of about 1,150,283 (286)

INdividual Vocational and Educational Support Trial (INVEST) for young people with borderline personality disorder: study protocol for a randomised controlled trial

Trials, 2020
Background The clinical onset of borderline personality disorder (BPD) usually occurs in young people (aged 12–25 years) and commonly leads to difficulty achieving and maintaining vocational (education and/or employment) engagement.
Andrew M. Chanen, Katie Nicol, Jennifer K. Betts, Gary R. Bond, Cathrine Mihalopoulos, Henry J. Jackson, Katherine N. Thompson, Martina Jovev, Hok Pan Yuen, Gina Chinnery, Judith Ring, Kelly Allott, Louise McCutcheon, Ashleigh P. Salmon, Eoin Killackey   +14 more
doaj   +1 more source

The potential of technology for enhancing individual placement and support supported employment. [PDF]

Psychiatric Rehabilitation Journal, 2014
The potential of technology to enhance delivery and outcomes of Individual Placement and Support (IPS) supported employment.IPS supported employment has demonstrated robust success for improving rates of competitive employment among individuals with psychiatric disabilities.
Sarah E, Lord, Susan R, McGurk, Joanne, Nicholson, Elizabeth A, Carpenter-Song, Justin S, Tauscher, Deborah R, Becker, Sarah J, Swanson, Robert E, Drake, Gary R, Bond   +8 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Job maintenance by supported employment: an overview of the Supported Employment plus trial

Frontiers in Public Health, 2015
The number of days of absence from work associated with mental illness has risen dramatically in the past ten years in Germany. Companies are challenged by this issue and seek help for the physical and mental health of their employees.
Wolfram eKawohl, Wolfram eKawohl, Wolfram eKawohl, Jörn eMoock, Sandra eHeuchert, Wulf eRössler, Wulf eRössler   +6 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Return to practice: supporting diagnostic radiographers back into the workforce. [PDF]

, 2017
The ‘Return to Practice in Diagnostic Radiography’ programme at one UK university provides a structured way for returnees to meet the Health and Care Professions Council (HCPC) return to practice requirements.
Errett, Sue, Hyde, Emma
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Predicting satisfaction with vocational status among people with serious mental illness in vocational services: the role of perceived skills and support

Frontiers in Psychiatry
BackgroundThis study aimed to explore the role of perceived skills and support in satisfaction with vocational status to better address the vocational needs and recovery goals of individuals with serious mental illness (SMI).
Gili Hoter Ishay, Gili Hoter Ishay, Gil Goldzweig, Ilanit Hasson-Ohayon, Marc Gelkopf, Efrat Shadmi, David Roe   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source