Results 61 to 70 of about 256,812 (272)

Individual placement and support: from research to practice [PDF]

Advances in Psychiatric Treatment, 2008
Vocational rehabilitation for people with severe mental health problems is poorly developed in the UK. Although there is a clear evidence base indicating the effectiveness of approaches to helping people with severe mental health problems gain and retain employment there is generally a lack of awareness of this evidence.
Miles Rinaldi, Rachel Perkins, Edmund Glynn, Tatiana Montibeller, Mark Clenaghan, Joan Rutherford   +5 more
openaire   +1 more source

Individual Placement and Support Cost-Benefit and Outcomes Model (IPS-Mod): code repository [PDF]

Code repository for data and analysis supporting the development of Individual Placement and Support (IPS) cost-benefit ...
Damon Morris, Holly Clarke
core   +1 more source

Personal experiences of recovery facilitated by participation in an individual placement and support intervention [PDF]

, 2017
IntroductionIndividual placement and support (IPS) is an evidence-based intervention where IPS consultants support people with severe mental illness in achieving competitive employment. IPS is a recovery-oriented intervention, but vast evidence regarding
I. Gammelgaard, Petersen, Kirsten Schultz; id_orcid, L.F. Eplov, Stenager, E., Eplov, L. F., E. Stenager, Gammelgaard, I., K.S. Petersen   +7 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Individualized Placement and Support Supported Employment for Justice-involved Homeless and Unemployed Veterans

Medical Care, 2021
Background: Homelessness is a significant issue affecting the general US population. Two subsets of the population overrepresented in the US homeless population are justice involved individuals and Veterans. However, relatively little research has addressed alleviating homelessness in justice-involved Veterans (JIV).
James P, LePage, William Blake, Martin, April M, Crawford, Avery, Rock, Julie A, Parish Johnson, Edward L, Washington   +5 more
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Coaching im Individual Placement and Support (IPS)

dvb forum
Der Beitrag gliedert sich in zwei Teile. Im ersten Abschnitt wird ein allgemeiner Überblick über Coachingansätze gegeben und die Entwicklung hin zum Jobcoaching umrissen. Da ein großer Teil der Langzeitarbeitslosen unter psychischen Störungen leidet und ein großer Teil der in klinischer Behandlung befindlichen Menschen aus dem Arbeitsleben exkludiert ...
Dorothea Jäckel, Ulrike Skorupa
openaire   +2 more sources