Results 11 to 20 of about 13,873 (237)

Comparison of Individual Radiosensitivity to γ-Rays and Carbon Ions. [PDF]

Front Oncol, 2016
Carbon ions are an up-and-coming ion species, currently being used in charged particle radiotherapy. As it is well established that there are considerable interindividual differences in radiosensitivity in the general population that can significantly influence clinical outcomes of radiotherapy, we evaluate the degree of these differences in the ...
Shim G, Normil MD, Testard I, Hempel WM, Ricoul M, Sabatier L.   +5 more
europepmc   +7 more sources

Individual Radiosensitivity and its Relevance to Health Physics

Dose-Response, 2007
Radiation protection regulations have been established to reduce exposure of individuals to acceptable safe levels. These limits assume that people have similar responses to ionizing radiation and that there is no variation in individual radiation risk ...
Kara Schnarr, Ian Dayes, Jinka Sathya, Douglas Boreham   +3 more
doaj   +3 more sources

Predicting Factors of Radiosensitivity in Individual Radiotherapy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
BACKGROUND AND OBJECTIVE: Radiation dose in oncology protocols is different for each patient according to the type and grade of the tumor, as well as adjuvant therapies.
Sh ghasemi, A Shabestani Monfared, S Borzoueisileh, E Zabihi, M Amiri, S Abedian   +5 more
doaj   +2 more sources

Active caspase-3 expression levels as bioindicator of individual radiosensitivity [PDF]

Anais da Academia Brasileira de Ciências, 2017
Several molecules and events involved in cell response to radiation-induced damage have been investigated towards a personalized radiotherapy. Considering the importance of active caspase-3 in the proteolytic cascade that ensures radiation-induced ...
NEYLIANE F.G. DOS SANTOS, RAFAEL F. SILVA, MARCELA M.P.L. PINTO, EDVANE B. DA SILVA, DEBORAH R. TASAT, ADEMIR AMARAL   +5 more
doaj   +5 more sources

Predicting Normal Tissue Radiotoxicity in Radiotherapy Patients Based on the Individual Radiosensitivity Using Three-Color Fluorescence In Situ Hybridization: A Literature Review

Indonesian Journal of Cancer, 2022
Background: The variability of clinical response in radiotherapy (RT) patients revealed that individual radiosensitivity exists in humans. Although several techniques for radiosensitivity assessment are available, fluorescence in situ hybridization (FISH)
Dwi Ramadhani , Isnaini Farida, Arum Wulansari , Wiwin Mailana, Hartini Ahadiyatur Ru’yi, Syarifatul Ulya, Sofiati Purnami, Nastiti Rahajeng, Devita Tetriana, Iin Kurnia, Mukh Syaifudin   +10 more
doaj   +1 more source

Ex Vivo Chromosomal Radiosensitivity Testing in Patients with Pathological Germline Variants in Breast Cancer High-Susceptibility Genes BReast CAncer 1 and BReast CAncer 2

Current Issues in Molecular Biology, 2023
Background: Individual radiosensitivity is an important factor in the occurrence of undesirable consequences of radiotherapy. The potential for increased radiosensitivity has been linked to highly penetrant heterozygous mutations in DNA repair genes such
Tara Zuhair Kassem, Marius Wunderle, Lukas Kuhlmann, Matthias Ruebner, Hanna Huebner, Juliane Hoyer, André Reis, Peter A. Fasching, Matthias W. Beckmann, Carolin C. Hack, Rainer Fietkau, Luitpold Distel   +11 more
doaj   +1 more source

NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations

Scientific Reports, 2021
Genetic information is protected against a variety of genotoxins including ionizing radiation (IR) through the DNA double-strand break (DSB) repair machinery.
Keita Tomioka, Tatsuo Miyamoto, Silvia Natsuko Akutsu, Hiromi Yanagihara, Kazumasa Fujita, Ekaterina Royba, Hiroshi Tauchi, Takashi Yamamoto, Iemasa Koh, Eiji Hirata, Yoshiki Kudo, Masao Kobayashi, Satoshi Okada, Shinya Matsuura   +13 more
doaj   +1 more source

Search for polymorphic variants of candidate genes contributing to individual radiosensitivity

Бюллетень сибирской медицины, 2023
Background. Cytogenetic damage (СD) in lymphocytes induced by low doses (up to 0.1 Sv) of ionizing radiation (IR) is the main cytogenetic sign of individual radiosensitivity of the human body.
D. S. Isubakova, N. V. Litviakov, O. S. Tsymbal, T. V. Usova, M. Yu. Tsyplenkova, I. V. Milto, R. M. Takhauov   +6 more
doaj   +1 more source

Intra-individual variation in G2 chromosomal radiosensitivity [PDF]

Mutagenesis, 2012
Intra-individual variation in G(2) chromosomal radiosensitivity was examined by repeatedly taking blood samples from two individuals. Two healthy female volunteers provided a total of 44 blood samples, Donor 1 gave 28 samples in four time periods between 2001 and 2006 and Donor 2 gave 16 samples in two of the same time periods.
Curwen, Gillian B, Cadwell, Kevin K, Tawn, E Janet, Winther, Jeanette F, Boice, John D   +4 more
openaire   +3 more sources

Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients

BMC Geriatrics, 2018
Background The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to determine individual ...
Barbara Schuster, Anna Ellmann, Theresa Mayo, Judith Auer, Matthias Haas, Markus Hecht, Rainer Fietkau, Luitpold V. Distel   +7 more
doaj   +1 more source