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Epigenetic Factors of Individual Radiosensitivity and Adaptive Capacity
International Journal of Radiation Biology, 2020Purpose: Studying the relationship between epigenetic variability with different individual radiosensitivity and adaptive capacity.Material and method: Using a simple and convenient experimental model - maize seedlings with different germination terms and epigenetic patterns - the hypothesis was tested that homogeneous genetically but epigenetic ...
Daryna Sokolova
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A Standardized G2-Assay for the Prediction of Individual Radiosensitivity
Radiotherapy and Oncology, 2011An increased yield of chromatid breaks following G2-phase irradiation could be a marker of radiosensitivity-predisposing genes that respond to DNA damage. We have shown that the dynamic nature of chromatin-nucleoprotein complex, which is capable of rapid unfolding, disassembling, assembling and refolding, affects repair of radiation-induced DNA-lesions
Georgia I Terzoudi, Gabriel E Pantelias
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Impact of Homologous Recombination on Individual Cellular Radiosensitivity
Radiotherapy and Oncology, 2009Individual radiosensitivity as measured with in vitro irradiated lymphocytes using metaphase analysis can predict the risk of normal tissue effects after radiotherapy. This parameter is considered to be primarily determined by the cellular repair capacity of DNA double-strand breaks (DSBs). It is now tested to which extent this capacity also depends on
Kerstin Borgmann, Ekkehard Dikomey
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Chromosomal radiosensitivity of HIV positive individuals
International Journal of Radiation Biology, 2010Radiosensitivity in relation to the human immunodeficiency virus (HIV) status is important in South Africa as the prevalence of HIV infections is high. In this study the in vitro chromosomal radiosensitivity of HIV positive individuals was investigated and compared with that of HIV negative individuals.Blood samples from 59 HIV positive and 39 HIV ...
Ans, Baeyens +5 more
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Functional Assays for Individual Radiosensitivity: A Critical Review
Seminars in Radiation Oncology, 2017A complete understanding of the mechanisms of the response to radiation would help in a better evaluation of the radiation-induced risks. To this aim, individual radiosensitivity, that is, the proneness to radiation-induced tissue reactions attributable to cell death, has been documented since the beginning of the 20th century.
Ferlazzo, M.L. +2 more
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Analysis of Individual Differences in Radiosensitivity Using Genome Editing [PDF]
Annals of the ICRP, 2016 Current standards for radiological protection of the public have been uniformly established. However, individual differences in radiosensitivity are suggested to exist in human populations, which could be caused by nucleotide variants of DNA repair genes.
Shinya Matsuura +2 more
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