Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Pronouncing that being is one in the works of Ibn Arebi, Meister Eckhart and Baruch de Spinoza [PDF]
Kom: Časopis za Religijske Nauke, 2017 In different traditions, the question of being came according to the different epistemologies that traditions represented: those who followed the rational method would ask the question of being that could be proven in a rational way, those who ...
Grbić Safer
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Wuthering Heights, Plato\u27s Symposium, and the Unity of Being
, 2013 The purpose of this thesis is to investigate the potential influence of Plato\u27s Symposium on Emily Brontë\u27s Wuthering Heights, by analyzing similarities between the two texts.
Matzker, Faith Lynn
core
Government Alternation and Legislative Party Unity : The Case of Italy, 1988–2008
, 2012 The large literature on legislative party unity identifies the confidence relationship, i.e. the threat of being voted out of office and losing agenda setting powers, as well as cabinet membership, as two crucial institutional sources of party discipline.
F. Zucchini, L. Curini
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
"The unity of the spirit": the trinity, the church and love in Saint Augustine of Hippo [PDF]
, 2006 "The unity ofthe Spirit": the Trinity, the Church and love in Saint Augustine of Hippo. Augustine of Hippo spent most of his career contending for the cause of the unity of the Church.
Hoskins, John Paul
core
The Unity of the Internal and External in Homer [PDF]
This work was written for the Midlands Conference of Critical Thought which took place on the 24th and 25th April 2025 at the University of Derby. It concerns the moments in the epics of Homer where the internal appears to be expressed through the ...
Milward, Andrew
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Person and experience : a study in the thought of Edgard Sheffield Brightman
, 2015 This dissertation comprises exegesis and critique of the personalistic idealism of Edgar Sheffield Brightman (1884 - 1953). Chapter One offers a biography of Brightman's life and identifies the intellectual heritage out of which he emerged and in which ...
Gillies, Robert A.
core