Results 131 to 140 of about 101,556 (381)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Cosa potrebbe un corpo? Il dividuale e l’individuazione della filosofia contemporanea [PDF]
La Deleuziana, 2015 Deleuze and Guattari's concept of “dividual”, as the result of a process of individualization and the digital codification of social life within societies of control, is one of the most discussed concepts in this first part of the 21st century. According
Sara Baranzoni, Paolo Vignola
doaj
Separation-individuation and ego identity status in late adolescence: A two-year longitudinal study [PDF]
, 1988 Jane Kroger, Stephen Haslett
openalex +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Biopolitical Immanence or Whether Foucault and Deleuze Still Matter [PDF]
La Deleuziana, 2015 The dream of control is to be, simultaneously, absolutely generic (beyond individuation) and absolutely singular; seeing all and seeing every “person” in her singularity, purely immanent to her very life, her bios: a prosthetic God.
Mohammad-Ali Rahebi
doaj
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The philosophy of language and the Ontology of Knowledge [PDF]
, 2019 Objective The relations between thought and reality are studied in many fields of philosophy and science. Examples include ontology and metaphysics in general, linguistics, neuroscience and even mathematics. Each one has its postulates, its language, its
Boucon, Jean-Louis
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyOsteoporosis, arthritis, and fractures are examples of orthopedic illnesses that not only significantly impair patients’ quality of life but also complicate and raise the expense of therapy. It has been discovered in recent years that the pathophysiology
Zhuce Shao +3 more
doaj +1 more source
A Pluralistic Theory of Wordhood [PDF]
What are words and how should we individuate them? There are two main answers on the philosophical market. For some, words are bundles of structural-functional features defining a unique performance profile.
Adger D. +20 more
core +1 more source