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Oral administration of indole-3-lactic acid alleviates activity-based anorexia in female mice
NeuropharmacologyXinyu Tang +7 more
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Brain, Behavior, and Immunity
Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and its metabolites, though the specific mechanisms have remained unclear. In our study, we used a multi-omics approach to identify specific microbial strains and metabolites that could potentially mitigate amyloidopathy in 5xFAD mice, a widely used model for AD research.
Hyun, Kim +18 more
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Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and its metabolites, though the specific mechanisms have remained unclear. In our study, we used a multi-omics approach to identify specific microbial strains and metabolites that could potentially mitigate amyloidopathy in 5xFAD mice, a widely used model for AD research.
Hyun, Kim +18 more
openaire +2 more sources
Journal of Agricultural and Food Chemistry, 2023
In this study, the effectors and mechanisms of Bifidobacterium bifidum FL-276.1 and B. bifidum FL-228.1 in alleviating dextran sulfate sodium (DSS)-induced colitis were investigated. Both FL-276.1 and FL-228.1 significantly alleviated DSS-induced colitis, whether they were supplemented from the beginning of the experiment (whole course intervention) or
Qingyu Cui +14 more
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In this study, the effectors and mechanisms of Bifidobacterium bifidum FL-276.1 and B. bifidum FL-228.1 in alleviating dextran sulfate sodium (DSS)-induced colitis were investigated. Both FL-276.1 and FL-228.1 significantly alleviated DSS-induced colitis, whether they were supplemented from the beginning of the experiment (whole course intervention) or
Qingyu Cui +14 more
openaire +2 more sources
The Journal of Dermatology
ABSTRACTPsoriasis is a chronic inflammatory skin disease whose pathogenesis involves dysregulation of the skin microbiota. Multiple studies have revealed alterations in microbial community composition between psoriatic lesions and healthy skin. However, the metabolic pathways of the skin microbiota, particularly those involving tryptophan metabolism ...
Yangang Zhang +9 more
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ABSTRACTPsoriasis is a chronic inflammatory skin disease whose pathogenesis involves dysregulation of the skin microbiota. Multiple studies have revealed alterations in microbial community composition between psoriatic lesions and healthy skin. However, the metabolic pathways of the skin microbiota, particularly those involving tryptophan metabolism ...
Yangang Zhang +9 more
openaire +1 more source
1995
The free-living nitrogen-fixing soil bacterium Azospirillum brasilense Sp7 produces indole-3-acetic acid (IAA) from tryptophan (Trp). Ammonia and oxygen are involved in the processes of IAA production and nitrogen fixation. Oxygen is required during the conversion of Trp to IAA via indole-3-acetamide (IAM).
Tami Bar, Yaacov Okon
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The free-living nitrogen-fixing soil bacterium Azospirillum brasilense Sp7 produces indole-3-acetic acid (IAA) from tryptophan (Trp). Ammonia and oxygen are involved in the processes of IAA production and nitrogen fixation. Oxygen is required during the conversion of Trp to IAA via indole-3-acetamide (IAM).
Tami Bar, Yaacov Okon
openaire +1 more source
Life Sciences
This study investigates the potential of Bifidobacterium bifidum 1007478 (BB478) and its metabolite indole-3-lactic acid (ILA) in alleviating non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD) and fructose exposure.A zebrafish model of NASH was established by exposure to HFD and fructose.
Chao, Tian +4 more
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This study investigates the potential of Bifidobacterium bifidum 1007478 (BB478) and its metabolite indole-3-lactic acid (ILA) in alleviating non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD) and fructose exposure.A zebrafish model of NASH was established by exposure to HFD and fructose.
Chao, Tian +4 more
openaire +2 more sources
Journal of Agricultural and Food Chemistry
Our previous studies have shown that Lactiplantibacillus plantarum DPUL-S164-derived indole-3-lactic acid (ILA) ameliorates intestinal epithelial cell barrier injury by activating aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways and promoting tight junction protein expression.
Arong Wang +4 more
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Our previous studies have shown that Lactiplantibacillus plantarum DPUL-S164-derived indole-3-lactic acid (ILA) ameliorates intestinal epithelial cell barrier injury by activating aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways and promoting tight junction protein expression.
Arong Wang +4 more
openaire +2 more sources
Talanta
A highly sensitive and selective electrochemical sensing platform with self-assembled porous 3-D trimetallic (Pd, Fe, and Co) hybrid anchored on a cost-effective and high-conducting carbon paper (CP) synthesized via a facile and cost-effective hydrothermal impregnation and thermal reduction technique was developed for determining indole-3-lactic acid ...
Dieudonne Tanue Nde +8 more
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A highly sensitive and selective electrochemical sensing platform with self-assembled porous 3-D trimetallic (Pd, Fe, and Co) hybrid anchored on a cost-effective and high-conducting carbon paper (CP) synthesized via a facile and cost-effective hydrothermal impregnation and thermal reduction technique was developed for determining indole-3-lactic acid ...
Dieudonne Tanue Nde +8 more
openaire +2 more sources
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Plant polysaccharides are effective components that widely present in traditional Chinese medicine(TCM), exhibiting rich biological activities. However, as most plant polysaccharides cannot be directly absorbed and utilized by the human digestive system, it is now believed that their mode of action mainly involves interaction with intestinal microbiota,
Yi-Yang, Bao +8 more
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Plant polysaccharides are effective components that widely present in traditional Chinese medicine(TCM), exhibiting rich biological activities. However, as most plant polysaccharides cannot be directly absorbed and utilized by the human digestive system, it is now believed that their mode of action mainly involves interaction with intestinal microbiota,
Yi-Yang, Bao +8 more
openaire +1 more source