Results 161 to 170 of about 16,665 (202)
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Indole-3-lactic acid is a weak auxin analogue but not an anti-auxin

Journal of Plant Growth Regulation, 1995
Indole-3-lactic acid (ILA) is a naturally occurring indole derivative, preferably detected in soil bacteria and fungi and only in low amounts in plants. T-DNA gene 5 of Agrobacterium tumefaciens was found to be involved in the synthesis of ILA in transformed plant tissues, but the physiologic relevance for ILA production in plants is unclear.
Stefanie Sprunck   +2 more
openaire   +1 more source

Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation

Brain, Behavior, and Immunity
Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and its metabolites, though the specific mechanisms have remained unclear. In our study, we used a multi-omics approach to identify specific microbial strains and metabolites that could potentially mitigate amyloidopathy in 5xFAD mice, a widely used model for AD research.
Hyun, Kim   +18 more
openaire   +2 more sources

Bifidobacterium bifidum Ameliorates DSS-Induced Colitis in Mice by Regulating AHR/NRF2/NLRP3 Inflammasome Pathways through Indole-3-lactic Acid Production

Journal of Agricultural and Food Chemistry, 2023
In this study, the effectors and mechanisms of Bifidobacterium bifidum FL-276.1 and B. bifidum FL-228.1 in alleviating dextran sulfate sodium (DSS)-induced colitis were investigated. Both FL-276.1 and FL-228.1 significantly alleviated DSS-induced colitis, whether they were supplemented from the beginning of the experiment (whole course intervention) or
Qingyu Cui   +14 more
openaire   +2 more sources

Mechanisms and Therapeutic Potential of Key Anti-inflammatory Metabiotics: Trans-Vaccenic Acid, Indole-3-Lactic Acid, Thiamine, and Butyric Acid

Probiotics and Antimicrobial Proteins
Identifying metabolites produced by probiotic bacteria, also known as metabiotics, is becoming increasingly common due to their anti-inflammatory, anti-obesogenic, and immunomodulatory effects. Postbiotics alongside diet, regulate both physical and mental health, as the microbiota members can interact physically with host cells or through secretion of ...
Muñoz-Olivos Cristina   +5 more
openaire   +2 more sources

Indole‐3‐Lactic Acid Inhibits Keratinocyte Proliferation Through the Aryl Hydrocarbon Receptor in Psoriasis

The Journal of Dermatology
ABSTRACTPsoriasis is a chronic inflammatory skin disease whose pathogenesis involves dysregulation of the skin microbiota. Multiple studies have revealed alterations in microbial community composition between psoriatic lesions and healthy skin. However, the metabolic pathways of the skin microbiota, particularly those involving tryptophan metabolism ...
Yangang Zhang   +9 more
openaire   +1 more source

Room Temperature Phosphorescence Characteristics of Indole-3-Propionic Acid, DL-Indole-3-Lactic Acid, and Indole-3-Glycolic Acid on Low-Background Paper Substrate

Microchemical Journal, 1995
Room temperature phosphorescence characteristics of indole-3-propionic acid, DL-indole-3-lactic acid, and indole-3-glycolic acid were studied on a low-background paper substrate. The influence of potassium iodide, thallium (I) nitrate, silver (I) nitrate, and lead (II) acetate on the intensities of the analyte signals was evaluated.
J. Deribamar, A.D. Campiglia
openaire   +1 more source

Conversion of Tryptophan, Indole-3-Pyruvic Acid, Indole-3-Lactic Acid and Indole to Indole-3-Acetic Acid by Azospirillum brasilense Sp7

1995
The free-living nitrogen-fixing soil bacterium Azospirillum brasilense Sp7 produces indole-3-acetic acid (IAA) from tryptophan (Trp). Ammonia and oxygen are involved in the processes of IAA production and nitrogen fixation. Oxygen is required during the conversion of Trp to IAA via indole-3-acetamide (IAM).
Tami Bar, Yaacov Okon
openaire   +1 more source

Bifidobacterium bifidum 1007478 derived indole-3-lactic acid alleviates NASH via an aromatic hydrocarbon receptor-dependent pathway in zebrafish

Life Sciences
This study investigates the potential of Bifidobacterium bifidum 1007478 (BB478) and its metabolite indole-3-lactic acid (ILA) in alleviating non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD) and fructose exposure.A zebrafish model of NASH was established by exposure to HFD and fructose.
Chao, Tian   +4 more
openaire   +2 more sources

Indole-3-lactic acid derived from tryptophan metabolism promotes trophoblast migration and invasion by activating the AhR/VCAN pathway

Placenta
Preeclampsia (PE) is a life-threatening condition that is unique to human pregnancy, and it is a leading cause of maternal and neonatal morbidity and mortality. Currently, the only definitive treatment for PE is delivery of the placenta. Several studies have suggested that the gut microbiota and its derived metabolites may be associated with PE.
Yingying Wei   +7 more
openaire   +2 more sources

Lactiplantibacillus plantarum-Derived Indole-3-lactic Acid Ameliorates Intestinal Barrier Integrity through the AhR/Nrf2/NF-κB Axis

Journal of Agricultural and Food Chemistry
Our previous studies have shown that Lactiplantibacillus plantarum DPUL-S164-derived indole-3-lactic acid (ILA) ameliorates intestinal epithelial cell barrier injury by activating aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways and promoting tight junction protein expression.
Arong Wang   +4 more
openaire   +2 more sources

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