Results 151 to 160 of about 545,403 (187)
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Cell Metabolism, 2023
Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation ...
Huihui Ma, Qihui Zhu, Yuyu Xu
exaly +3 more sources
Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation ...
Huihui Ma, Qihui Zhu, Yuyu Xu
exaly +3 more sources
Indole-3-lactic acid as a tryptophan metabolite produced by Bifidobacterium spp
Applied and Environmental Microbiology, 1979Fifty-one strains of the genus Bifidobacterium have been found to accumulate indole-3-lactic acid in culture broth. The isolated metabolite was identified through mass and nuclear magnetic resonance spectroscopy. All the microorganisms tested, as resting cells, have been shown to be able to convert L-tryptophan into L-indole-3-lactic acid.
F, Aragozzini +3 more
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Indole-3-lactic acid is a weak auxin analogue but not an anti-auxin
Journal of Plant Growth Regulation, 1995Indole-3-lactic acid (ILA) is a naturally occurring indole derivative, preferably detected in soil bacteria and fungi and only in low amounts in plants. T-DNA gene 5 of Agrobacterium tumefaciens was found to be involved in the synthesis of ILA in transformed plant tissues, but the physiologic relevance for ILA production in plants is unclear.
Stefanie Sprunck +2 more
openaire +1 more source
The Journal of Dermatology
ABSTRACT Psoriasis is a chronic inflammatory skin disease whose pathogenesis involves dysregulation of the skin microbiota. Multiple studies have revealed alterations in microbial community composition between psoriatic lesions and healthy skin.
Yangang Zhang +9 more
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ABSTRACT Psoriasis is a chronic inflammatory skin disease whose pathogenesis involves dysregulation of the skin microbiota. Multiple studies have revealed alterations in microbial community composition between psoriatic lesions and healthy skin.
Yangang Zhang +9 more
openaire +2 more sources
Oral administration of indole-3-lactic acid alleviates activity-based anorexia in female mice
NeuropharmacologyAnorexia nervosa (AN) is a severe psychiatric disorder characterized by extreme dietary restriction, pronounced weight loss, and disturbed energy metabolism. In recent years, increasing attention has been given to the role of the gut microbiota and its tryptophan-derived metabolites in modulating host neural function and feeding behavior via the gut ...
Xinyu Tang +7 more
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Brain, Behavior, and Immunity
Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and its metabolites, though the specific mechanisms have remained unclear. In our study, we used a multi-omics approach to identify specific microbial strains and metabolites that could potentially mitigate amyloidopathy in 5xFAD mice, a widely used model for AD research.
Hyun, Kim +18 more
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Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and its metabolites, though the specific mechanisms have remained unclear. In our study, we used a multi-omics approach to identify specific microbial strains and metabolites that could potentially mitigate amyloidopathy in 5xFAD mice, a widely used model for AD research.
Hyun, Kim +18 more
openaire +2 more sources