Results 1 to 10 of about 487,159 (190)

Indole-3-propionic acid promotes hepatic stellate cells inactivation [PDF]

Journal of Translational Medicine
Background & aims We have previously reported that the serum levels of gut-derived tryptophan metabolite indole-3-propionic acid (IPA) are lower in individuals with liver fibrosis.
Mariana Ilha, Ratika Sehgal, Johanna Matilainen, Kirsi Rilla, Dorota Kaminska, Shrey Gandhi, Ville Männistö, Charlotte Ling, Stefano Romeo, Päivi Pajukanta, Eija Pirinen, Kirsi A. Virtanen, Kirsi H. Pietiläinen, Maija Vaittinen, Jussi Pihlajamäki   +14 more
doaj   +7 more sources

New Indole-3-Propionic Acid and 5-Methoxy-Indole Carboxylic Acid Derived Hydrazone Hybrids as Multifunctional Neuroprotectors

Antioxidants, 2023
In light of the known neuroprotective properties of indole compounds and the promising potential of hydrazone derivatives, two series of aldehyde-heterocyclic hybrids combining those pharmacophores were synthesized as new multifunctional neuroprotectors.
Neda Anastassova, Denitsa Stefanova, Nadya Hristova-Avakumova, Irina Georgieva, Magdalena Kondeva-Burdina, Miroslav Rangelov, Nadezhda Todorova, Rumiana Tzoneva, Denitsa Yancheva   +8 more
doaj   +7 more sources

The Mechanism Underlying the Influence of Indole-3-Propionic Acid: A Relevance to Metabolic Disorders

Frontiers in Endocrinology, 2022
The increasing prevalence of metabolic syndrome has become a serious public health problem. Certain bacteria-derived metabolites play a key role in maintaining human health by regulating the host metabolism.
Binbin Zhang, Binbin Zhang, Minjie Jiang, Jianan Zhao, Yu Song, Weidong Du, Junping Shi, Junping Shi   +7 more
doaj   +5 more sources

The Neuroprotective Role of Indole-3-Propionic Acid in Migraine Pathophysiology [PDF]

Medicina
Background and Objectives: Migraine is a leading cause of disability worldwide, with complex pathophysiological mechanisms involving oxidative and nitrosative stress.
Dilek Agircan, Seyhan Taskin, Murat Cekic, Hakim Celik   +3 more
doaj   +4 more sources

Microbiota-Derived Tryptophan Metabolite Indole-3-Propionic Acid-Emerging Role in Neuroprotection [PDF]

Molecules
In recent years, gut–brain axis signaling has been recognized as an essential factor modifying behavior, mood, cognition, and cellular viability under physiological and pathological conditions.
Maja Owe-Larsson, Dominik Drobek, Paulina Iwaniak, Renata Kloc, Ewa M. Urbanska, Mirosława Chwil   +5 more
doaj   +5 more sources

Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites. [PDF]

Eur J Immunol
In recent years, we have witnessed a rapidly growing interest in the intricate communications between intestinal microorganisms and the host immune system.
Schütz B, Krause FF, Taudte RV, Zaiss MM, Luu M, Visekruna A.   +5 more
europepmc   +5 more sources

Indole-3-propionic acid supplementation during in vitro maturation improves in vitro production of porcine embryos [PDF]

BMC Veterinary Research
Background Oxidative stress is a critical factor affecting the maturation and developmental competence of porcine oocytes during in vitro culture, reducing the efficiency of blastocyst formation. Antioxidant supplementation in the culture medium has been
Yuichiro Nakayama, Takeshige Otoi, Namula Zhao, Suong Thi Nguyen, Nanaka Torigoe, Qyingi Lin, Liu Bin, Oky Setyo Widodo, Theerawat Tharasanit, Kaywalee Chatdarong, Maki Hirata, Megumi Nagahara, Fuminori Tanihara   +12 more
doaj   +4 more sources

Indole-3-propionic acid regulates lateral root development by targeting auxin signaling in Arabidopsis [PDF]

iScience
Summary: Indole-3-propionic acid (IPA) is known to be a microbe-derived compound with a similar structure to the phytohormone auxin (indole-3-acetic acid, IAA). Previous studies reported that IPA exhibited auxin-like bioactivities in plants. However, the
Yue Sun, Zhisen Yang, Caoli Zhang, Jing Xia, Yawen Li, Xin Liu, Linfeng Sun, Shutang Tan   +7 more
doaj   +4 more sources

The Tryptophan Metabolite Indole-3-Propionic Acid Raises Kynurenic Acid Levels in the Rat Brain In Vivo. [PDF]

Int J Tryptophan Res
Alterations in the composition of the gut microbiota may be causally associated with several brain diseases. Indole-3-propionic acid (IPrA) is a tryptophan-derived metabolite, which is produced by intestinal commensal microbes, rapidly enters the ...
Sathyasaikumar KV, Blanco-Ayala T, Zheng Y, Schwieler L, Erhardt S, Tufvesson-Alm M, Poeggeler B, Schwarcz R.   +7 more
europepmc   +5 more sources

Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets [PDF]

Animal Nutrition
Indole-3-propionic acid (IPA) has anti-inflammatory properties, which can be beneficial for weaned piglets with underdeveloped immune systems. The study explores the impact of IPA supplementation on growth performance, oxidative stress, and inflammation ...
Dongxu Ming, Xincong Xu, Xianren Jiang, Yanpin Li, Wenjuan Sun, Jiangbo Xiang, Mingyuan Huang, Yu Pi, Xilong Li   +8 more
doaj   +4 more sources