Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice [PDF]
Frontiers in NutritionBackgroundObesity is a chronic metabolic disease, mainly caused by excessive/abnormal fat accumulation, as well as accompanied by endotoxemia and chronic inflammation. Quercetin, a natural flavonoid, may alleviate obesity by regulating gut microbiota and
Jiaxin Lu +8 more
doaj +2 more sources
Elucidating the Interaction of Indole-3-Propionic Acid and Calf Thymus DNA: Multispectroscopic and Computational Modeling Approaches. [PDF]
FoodsIndole-3-propionic acid (IPA) is a plant growth regulator with good specificity and long action. IPA may be harmful to human health because of its accumulation in vegetables and fruits. Therefore, in this study, the properties of the interaction between calf thymus DNA (ctDNA) and IPA were systematically explored using multispectroscopic and ...
Wei Y, Zhang D, Pan J, Gong D, Zhang G.
europepmc +4 more sources
Archives of Physiology and Biochemistry, 2017 Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA).
Marianne Hokland +9 more
core +3 more sources
ImmunityAntibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx), but not in adulthood, were more susceptible to house dust mite (HDM ...
Olaf Perdijk +2 more
exaly +2 more sources
Carrot-Derived Rhamnogalacturonan-I Consistently Increases the Microbial Production of Health-Promoting Indole-3-Propionic Acid Ex Vivo. [PDF]
MetabolitesBackground: Using dietary interventions to steer the metabolic output of the gut microbiota towards specific health-promoting metabolites is often challenging due to interpersonal variation in treatment responses.
Mercenier A +5 more
europepmc +2 more sources
Hydrogen-deuterium exchange of indole-3-propionic acid with deuterated trifluoromethanesulfonic acid
Arkivoc, 2022 Indole-3-propionic acid (IPA), a member of the plant auxin family, plays an important role in biological activity. There are few reports on the preparation of deuterated IPA. Deuterated trifluoromethanesulfonic acid (TfOD) is a hydrogen-deuterium exchange reagent used for aromatic compounds.
Zhang, Wen +7 more
openaire +2 more sources
Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics
Frontiers in Pharmacology, 2022 The gut microbiota plays an important role in inflammatory diseases. Metabolites in the three metabolic pathways of tryptophan (Trp), histidine (His), and phenylalanine (Phe) can affect various inflammatory conditions, such as obesity, diabetes ...
Hui Xu +12 more
doaj +1 more source
Sedentary Plant-Parasitic Nematodes Alter Auxin Homeostasis via Multiple Strategies
Frontiers in Plant Science, 2021 Sedentary endoparasites such as cyst and root-knot nematodes infect many important food crops and are major agro-economical pests worldwide. These plant-parasitic nematodes exploit endogenous molecular and physiological pathways in the roots of their ...
Matthijs Oosterbeek +3 more
doaj +1 more source
Hydrogen-deuterium exchange of indole-3-propionic acid with deuterated trifluoromethanesulfonic acid
, 2023 Indole-3-propionic acid (IPA), a member of the plant auxin family, plays an important role in biological activity. There are few reports on the preparation of deuterated IPA.
Hashimoto, Makoto +7 more
core +1 more source
Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells [PDF]
, 2017 2017-11Indoxyl sulfate (IS) induces fibrosis and inflammation in kidneys via oxidative stress through the induction of transforming growth factor-β1 (TGF-β1) and monocyte chemotactic protein-1 (MCP-1).
Yisireyili, Maimaiti +4 more
core +1 more source