Biomolecules, 2020 A plant auxin hormone indole-3-acetic acid (IAA) can be assimilated by bacteria as an energy and carbon source, although no degradation has been reported for indole-3-propionic acid and indole-3-butyric acid.
Mikas Sadauskas +3 more
doaj +2 more sources
Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis [PDF]
Nutrients, 2021 Background and Aims: Gut microbiota-derived metabolites play a vital role in maintenance of human health and progression of disorders, including obesity and type 2 diabetes (T2D). Indole-3-propionic acid (IPA), a gut-derived tryptophan metabolite, has been recently shown to be lower in individuals with obesity and T2D.
Ratika Sehgal +2 more
exaly +4 more sources
Development of indole-3-propionic acid (OXIGON (TM)) for Alzheimer's disease
Journal of Molecular Neuroscience, 2002 The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON(TM)) is a potent anti-oxidant devoid of pro-oxidant activity.
Ziv, V. +5 more
core +4 more sources
Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function [PDF]
Frontiers in Medicine, 2021 Background: The gut microbiome has been linked to the onset of cardiometabolic diseases, in part facilitated through gut microbiota-dependent metabolites such as trimethylamine-N-oxide.
Maren Gesper +6 more
doaj +4 more sources
Fluorescent Nanosensor for Indole-3-Propionic Acid Detection in Gut Health Monitoring. [PDF]
Adv Healthc MaterThis work introduces a fluorescent nanosensor system with two optical modalities for detection of indole‐3‐propionic acid (IPA) gut metabolite: (1) blue‐emitting cationic conjugated polyelectrolyte (CP3) and (2) near‐infrared (NIR)‐emitting CP3‐wrapped single‐walled carbon nanotube (SWNT).
Ang MC +15 more
europepmc +2 more sources
Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants
Microorganisms, 2019 Recent studies have shown that metabolites produced by microbes can be considered as mediators of host-microbial interactions. In this study, we examined the production of tryptophan metabolites by Bifidobacterium strains found in the gastrointestinal ...
Takuma Sakurai +2 more
doaj +2 more sources
Microbiology Spectrum, 2022 The effects of using gut microbiota metabolites instead of live microorganisms to modulate sepsis-induced gut dysbiosis remain largely unknown. We assessed the effects of microbiota metabolite indole-3-propionic acid (IPA) on gut microbiota in mice ...
Heng Fang +12 more
doaj +3 more sources
Indole-3-Propionic Acid, a Gut Microbiota Metabolite, Protects Against the Development of Postoperative Delirium. [PDF]
Ann Surg, 2023 Objective: The aim was to determine preoperative gut microbiota metabolites that may be associated with postoperative delirium (POD) development in patients and further study in rodents. Summary Background Data: POD occurs in 9% to 50% of older patients undergoing anesthesia/surgery
Zhou X +24 more
europepmc +3 more sources
Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats [PDF]
Nutrients, 2019 Recent evidence suggests that tryptophan, an essential amino acid, may exert biological effects by means of tryptophan-derived gut bacteria products. We evaluated the potential contribution of tryptophan-derived bacterial metabolites to body weight gain.
Marcin Ufnal +5 more
core +3 more sources
Gut microbial metabolite indole-3-propionic acid inhibits inflammation and restores blood-milk barrier in S. aureus- induced mastitis by targeting aryl hydrocarbon receptor [PDF]
Frontiers in MicrobiologyBackgroundIndole-3-propionic acid (IPA) is a tryptophan metabolite produced by intestinal bacteria, which has functions such as penetrating tissue barriers and reducing tissue inflammatory reactions. In the present study, the therapeutic effect of IPA on
Lihua Zhao, Lei Jin, Yunhe Fu, Bin Yang
doaj +2 more sources