Results 21 to 30 of about 487,159 (190)

Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach. [PDF]

Gut
Background Both host and microbe metabolism of tryptophan (Trp) is altered in diabetes; however, the molecular mechanisms are incompletely understood. Objective We used strategies to increase either angiotensin converting enzyme-2 (ACE-
Prasad R, Adu-Rutledge Y, Ziani B, Floyd JL, Ready EL, Paul S, Sheini F, Sharma R, Rosencrans RF, Li Calzi S, Sielski MS, Medawar NG, Dutta R, Johnson EB, Qi X, Bansal M, Lamendella R, Wright JR, Verma SK, Boulton ME, Stevens BR, Vander Kooi CW, Sun RC, Oudit GY, Li Q, Grant MB.   +25 more
europepmc   +3 more sources

Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats [PDF]

Experimental and Molecular Medicine, 2019
Fatty liver disease: Bacterial metabolite protects liver by maintaining gut integrity A molecule made by beneficial microbes in the gut helps protect against a severe form of fatty liver disease by preventing bacterial toxins from leaking out of the ...
Ze-Hua Zhao, Feng-Zhi Xin, Yaqian Xue, Zhimin Hu, Yamei Han, Fengguang Ma, Da Zhou, Xiao-Lin Liu, Aoyuan Cui, Zhengshuai Liu, Yuxiao Liu, Jing Gao, Qin Pan, Yu Li, Jian-Gao Fan   +14 more
doaj   +3 more sources

Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction. [PDF]

Circ Res
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a common but poorly understood form of heart failure, characterized by impaired diastolic function. It is highly heterogeneous with multiple comorbidities, including obesity and diabetes, making human studies difficult ...
Wang YC, Koay YC, Pan C, Zhou Z, Tang W, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y, Lusis AJ.   +15 more
europepmc   +5 more sources

Enhanced growth and productivity of useful metabolites by indole-3-propionic acid treatment in Lemna aequinoctialis culture. [PDF]

BMC Plant Biol
Lemna aequinoctialis is a floating plant with potential uses as food, feed, biofuel, biomass, and pharmaceutical resources. In this study, we examined the effect of various concentrations of indole-3-propionic acid (IPA) on the growth, metabolomic, and transcriptomic profiles of L.
Lee YB, Cho JY, Jeong Y, Park S, Choi HK.   +4 more
europepmc   +3 more sources

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia [PDF]

Advanced Science
Bronchopulmonary dysplasia (BPD) disrupts the process of alveolar development, characterized by damage to alveolar epithelial type II cells (AEC II). The present study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic ...
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
doaj   +2 more sources

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis [PDF]

Advanced Science
Cardiac fibrosis, a key pathological feature of cardiac remodeling, is a major contributor to mortality in older patients with heart failure. The underlying mechanisms are complex, involving alterations in intercellular communication and chronic ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
doaj   +2 more sources

Cumulative Protective Effect of Melatonin and Indole-3-Propionic Acid against KIO3—Induced Lipid Peroxidation in Porcine Thyroid

Toxics, 2021
Iodine deficiency is the main environmental factor leading to thyroid cancer. At the same time iodine excess may also contribute to thyroid cancer. Potassium iodate (KIO3), which is broadly used in salt iodization program, may increase oxidative damage ...
Jan Stępniak, Małgorzata Karbownik-Lewińska, Stępniak Jan   +2 more
exaly   +2 more sources

Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state. [PDF]

Nat Commun
The contribution of chemotherapy-induced tissue injury to individual susceptibility to metastasis remains largely unexplored. We report that chemotherapy indirectly prevents colorectal cancer (CRC) liver metastases by inducing a lasting systemic ...
Bersier L, Lorenzo-Martin LF, Chiang YH, Durot S, Czauderna A, Yarahmadov T, Wyss Lozano T, Roci I, Kim J, Zamboni N, Vannini N, Pot C, Collet TH, Stroka D, Bernier-Latmani J, Lutolf MP, Becattini S, Koessler T, Petrova TV.   +18 more
europepmc   +2 more sources

Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis

Molecular Medicine, 2023
Background Osteoarthritis (OA) is a common chronic disease characterized by chronic inflammation and extracellular matrix degradation. Indole-3-propionic acid (IPA) is a tryptophan metabolite secreted by intestinal flora, which can exert anti ...
Huangming Zhuang, Xunshan Ren, Fuze Jiang, Panghu Zhou   +3 more
doaj   +3 more sources

Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor [PDF]

Molecular Medicine, 2023
Background The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect.
Shuang Wang, Liangzhi Xiong, Zhihua Ruan, Xiaofang Gong, Yanrong Luo, Chengyi Wu, Yu Wang, Hui Shang, Jingyi Chen   +8 more
doaj   +2 more sources