Results 51 to 60 of about 487,159 (190)

Esterified Indole-3-propionic Acid: A Novel Inhibitor against Cholinesterase Identified through Experimental and Computational Approaches [PDF]

ACS Omega
Jayanthi Sidhambaram, Penislusshiyan Sakayanathan, Chitra Loganathan, Ancy Iruthayaraj, Palvannan Thayumanavan   +4 more
doaj   +2 more sources

Plasma Gut Microbe-Derived Metabolites Associated with Peripheral Artery Disease and Major Adverse Cardiac Events

Microorganisms, 2022
Cardiovascular diseases are associated with gut dysbiosis, but the role of microbe-derived metabolites as biomarkers or modulators of cardiovascular disease are not well understood.
Karen J. Ho, Joel L. Ramirez, Rohan Kulkarni, Katharine G. Harris, Irene Helenowski, Liqun Xiong, C. Keith Ozaki, S. Marlene Grenon   +7 more
doaj   +1 more source

Serum microbiome-related metabolites—including short-chain fatty acids and indole derivatives—predict outcome and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a two-timepoint LC–MS study

Frontiers in Neurology
BackgroundDelayed cerebral ischemia (DCI) remains a major determinant of poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). Growing evidence suggests that gut microbiota–derived metabolites, including short-chain fatty acids (SCFAs) and ...
Blanka Nagybanyai-Nagy, Roland Tengölics, Csilla Sajben, Dominika Olasz, Attila Schwarcz, Tihamer Molnar, Peter Csecsei   +6 more
doaj   +1 more source

Gut microbiota-derived indole 3-propionic acid partially activates aryl hydrocarbon receptor to promote macrophage phagocytosis and attenuate septic injury

Frontiers in Cellular and Infection Microbiology, 2022
Sepsis is associated with a high risk of death, and the crosstalk between gut microbiota and sepsis is gradually revealed. Indole 3-propionic acid (IPA) is a gut microbiota-derived metabolite that exerts immune regulation and organ protective effects ...
Zhi-Bin Huang, Zhi-Bin Huang, Zhen Hu, Chen-Xin Lu, Si-Dan Luo, Yu Chen, Yu Chen, Zhi-Peng Zhou, Zhi-Peng Zhou, Jing-Juan Hu, Fang-Ling Zhang, Fan Deng, Ke-Xuan Liu   +12 more
doaj   +1 more source

Intermittent fasting promotes axonal regeneration through the gut microbiome derived metabolite: Indole-3-Propionic acid [PDF]

, 2020
Spontaneous functional mammalian axonal regeneration following injury fails. High density and fast axon regeneration across distances are needed for efficient repair in humans.
Serger, Elisabeth
core   +1 more source

Synthesis, Characterization, Thermal, and Antibacterial Studies of Organotin(Iv) Complexes of Indole-3-Butyric Acid and Indole-3-Propionic Acid

, 2014
Six organotin(IV) complexes of type Me2SnL2, Bu2SnL2, and Ph3SnL [where L = indole-3-butyric acid (1, 2 and 3) or indole-3-propionic acid (4, 5 and 6)] have been synthesized by the reactions of the corresponding diorganotin(IV) oxide and triphenyltin(IV)
Priti Malhotra (536793), A. K. Narula (536794), Asha Chilwal (536792)   +2 more
core   +1 more source

Effect of Tryptophan Analogs on Derepression of the Escherichia coli Tryptophan Operon by Indole-3-Propionic Acid [PDF]

Journal of Bacteriology, 1978
The abilities of 14 tryptophan analogs to repress the tryptophan ( trp ) operon have been studied in Escherichia coli cells derepressed by incubation with 0.25 mM indole-3-propionic acid (IPA). trp operon expression was monitored by measuring the specific activities of
Pauley, Robert J., Fredricks, Walter W., Smith, Oliver H.   +2 more
openaire   +3 more sources

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

The role of microbial indole metabolites in tumor

Gut Microbes
The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, can be converted by microorganisms via the indole pathway to indole metabolites such as ...
Dingjiacheng Jia, Zheng Kuang, Liangjing Wang   +2 more
doaj   +1 more source