Results 61 to 70 of about 487,159 (190)

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Stress accelerates hepatocellular carcinoma progression via a gut microbial-metabolite axis

Frontiers in Immunology
BackgroundHepatocellular carcinoma ranks among the most prevalent malignancies worldwide. While stress can modulate tumor initiation, progression, metastasis, and therapeutic response through diverse mechanisms, its specific role in hepatocellular ...
Zhe Hu, Pengfei Yue, Minlan Yuan, Zhenjie Zhang, Qiaoqi Li, Ting Yang, Yi Li, Bi-Sen Ding, Zhenxin Fan, Biao Yang, Zhongwei Cao   +10 more
doaj   +1 more source

Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli [PDF]

, 2020
The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-
Boyd, Joseph, Gerasimidis, Konstantinos, Fitzgerald, Eamonn, Roe, Andrew J, McIntosh, Anne, Connolly, James P R, Carpena, Nuria, Meikle, Lynsey M, Johnson, Síle A, Goldstone, Robert J, McConnachie, Ceilidh C, Hulme, Heather E, Wessel, Hannah M, Hasson, Conor, Ormsby, Michael J   +14 more
core   +1 more source

Azide‐to‐Diazo Transformation Facilitated by Michael Addition via Phosphazide Formation

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
A new type of Michael addition based on azide‐to‐diazo conversion is disclosed. This unusual transformation proceeds via 1,4‐addition accompanied by N─N bond cleavage of phosphazide intermediates under practical conditions. The high versatility of the resulting Michael adducts enables the synthesis of a wide variety of organonitrogen compounds ...
Tomoki Mano, Takahiro Yasuda, Gaku Orimoto, Suguru Yoshida   +3 more
wiley   +2 more sources

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Genome-Wide Identification, Functional Analysis and Expression Profiling of the Aux/IAA Gene Family in Tomato [PDF]

, 2012
Auxin is a central hormone that exerts pleiotropic effects on plant growth including the development of roots, shoots, flowers and fruit. The perception and signaling of the plant hormone auxin rely on the cooperative action of several components,among
Regad, Farid, Bassa, Carole, Delalande, Corinne, Mila, Isabelle, Zouine, Mohamed, Bouzayen, Mondher   +5 more
core   +1 more source

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, EarlyView.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, EarlyView.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source

A concise and regioselective synthesis of 6-bromo-5-methoxy-1H-indole-3-carboxylic acid and its derivatives: Strategic development toward core moiety of Herdmanine D

, 2020
A concise, regioselective and highly efficient strategy for the construction of 6-bromo-5-methoxy-1H-indole-3-carboxylic acid has been developed through trifluoroacetylated indole driven hydrolysis. The developed protocol has the advantage of selectively
Pankaj Sharma (58141), Gunjan Kashyap (8393136), Sunita Bhagat (8393139), Nutan Sharma (181815)   +3 more
core   +1 more source

Uncovering the specificity and predictability of tryptophan metabolism in lactic acid bacteria with genomics and metabolomics

Frontiers in Cellular and Infection Microbiology, 2023
Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan, Tong Pan, Zhangming Pei, Zhangming Pei, Zhifeng Fang, Hongchao Wang, Hongchao Wang, Jinlin Zhu, Jinlin Zhu, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang, Jianxin Zhao, Jianxin Zhao, Jianxin Zhao, Wei Chen, Wei Chen, Wei Chen, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu   +23 more
doaj   +1 more source