Profiling Analysis of Tryptophan Metabolites in the Urine of Patients with Parkinson’s Disease Using LC–MS/MS [PDF]
Pharmaceuticals, 2023 Although Parkinson’s disease (PD) is a representative neurodegenerative disorder and shows characteristic motor impediments, the pathophysiological mechanisms and treatment targets for PD have not yet been clearly identified.
So Hyeon Chung +4 more
doaj +5 more sources
The Role of Tryptophan Metabolites in Neuropsychiatric Disorders [PDF]
International Journal of Molecular Sciences, 2022 In recent decades, neuropsychiatric disorders such as major depressive disorder, schizophrenia, bipolar, etc., have become a global health concern, causing various detrimental influences on patients.
Majid Hassanzadeganroudsari +2 more
exaly +6 more sources
Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice [PDF]
FoodsAsthma is a prevalent respiratory disease. The present study is designed to determine whether gut microbiota-derived tryptophan metabolites alleviate allergic asthma inflammation in ovalbumin (OVA)-induced mice and explore the effect and potential ...
Hongchao Wang +5 more
doaj +5 more sources
Tryptophan metabolites and incident cardiovascular disease: The EPIC-Norfolk prospective population study [PDF]
Atherosclerosis, 2023 Background and aims: Cardiovascular disease (CVD) remains the largest cause of death globally due to various risk factors. One novel potential contributor to CVD might be the metabolism of the essential amino acid tryptophan (Trp), which through many ...
Charlotte J Teunis +2 more
exaly +3 more sources
Lung-Gut Microbiota and Tryptophan Metabolites Changes in Neonatal Acute Respiratory Distress Syndrome [PDF]
Journal of Inflammation ResearchJingli Yang,1– 4 Yu He,1– 5 Qing Ai,1– 4 Chan Liu,1– 4 Qiqi Ruan,1– 4 Yuan Shi1– 4 1Department of Neonatology, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2National Clinical Research Center for Child Health
Yang J, He Y, Ai Q, Liu C, Ruan Q, Shi Y
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Tryptophan metabolites clearance in hemodialyzed patients [PDF]
Amino AcidsHemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) complications ...
Izabela Zakrocka +8 more
doaj +4 more sources
Modulation of immunity by tryptophan microbial metabolites
Frontiers in Nutrition, 2023 Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and exogenous pathways, including the Kynurenine Pathway, the 5-Hydroxyindole Pathway (also the Serotonin pathway), and the Microbial pathway.
Li Siying
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Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
Gut Microbes, 2020 Commensal microbiota-dependent tryptophan catabolism within the gastrointestinal tract is known to exert profound effects upon host physiology, including the maintenance of epithelial barrier and immune function.
Fangcong Dong +10 more
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Microorganisms, 2023 The gut microbiome provides the host access to otherwise indigestible nutrients, which are often further metabolized by the microbiome into bioactive components.
Claire Shaw +2 more
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Chromatographic analysis of tryptophan metabolites [PDF]
Journal of Separation Science, 2017 The kynurenine pathway generates multiple tryptophan metabolites called collectively kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine dinucleotide. The first step in this pathway is tryptophan degradation, initiated by the rate‐limiting enzymes indoleamine 2,3‐dioxygenase, or tryptophan 2,3‐dioxygenase, depending on the ...
Ilona Sadok +2 more
exaly +4 more sources