Results 41 to 50 of about 855,125 (282)

Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy

Translational Psychiatry, 2022
Depression during and after pregnancy affects up to 20% of pregnant women, but the biological underpinnings remain incompletely understood. As pregnancy progresses, the immune system changes to facilitate fetal development, leading to distinct ...
Q. Sha, Zachary B. Madaj, Sarah A. Keaton, Martha L. Escobar Galvis, LeAnn Smart, S. Krzyzanowski, A. Fazleabas, R. Leach, T. Postolache, E. Achtyes, L. Brundin   +10 more
semanticscholar   +1 more source

Tryptophan metabolites in depression: Modulation by gut microbiota

Frontiers in Behavioral Neuroscience, 2022
Clinical depression is a multifactorial disorder and one of the leading causes of disability worldwide. The alterations in tryptophan metabolism such as changes in the levels of serotonin, kynurenine, and kynurenine acid have been implicated in the ...
I. Lukic, S. Ivkovic, M. Mitić, M. Adzic   +3 more
semanticscholar   +1 more source

Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model

Human Vaccines & Immunotherapeutics, 2020
In allergen-specific immunotherapy for asthma, antigens attached to dendritic cells increase the tryptophan metabolism in these cells and alter the Th17/Treg balance in the airways.
Qi Hu, Ling Jin, Jing Zeng, Jinyu Wang, Shimin Zhong, Wenting Fan, Wei Liao   +6 more
doaj   +1 more source

Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease

Amino Acids, 2022
The essential amino acid tryptophan (Trp) is metabolized by gut commensals, yielding in compounds that affect innate immune cell functions directly, but also acting on the aryl hydrocarbon receptor (AHR), thus regulating the maintenance of group 3 innate
N. Paeslack, M. Mimmler, S. Becker, Zhenling Gao, My Phung Khuu, A. Mann, F. Malinarich, Tommy Regen, C. Reinhardt   +8 more
semanticscholar   +1 more source

Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohortsResearch in context

EBioMedicine, 2023
Summary: Background: Since gut microbiome dysbiosis can cause inflammatory disorders by affecting host metabolism, we postulate that the gut microbiome and related metabolites could play a role in hand osteoarthritis.
Jie Wei, Zidan Yang, Jiatian Li, Yuqing Zhang, Weiya Zhang, Michael Doherty, Tuo Yang, Yuanheng Yang, Hui Li, Yilun Wang, Ziying Wu, Changjun Li, Guanghua Lei, Chao Zeng   +13 more
doaj   +1 more source

Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.

PLoS ONE, 2014
The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic halogenated aromatic hydrocarbons and is involved in a diverse array of biological processes.
Margaret M Lowe, Jeff E Mold, Bittoo Kanwar, Yong Huang, Alexander Louie, Michael P Pollastri, Cuihua Wang, Gautam Patel, Diana G Franks, Jennifer Schlezinger, David H Sherr, Allen E Silverstone, Mark E Hahn, Joseph M McCune   +13 more
doaj   +1 more source

Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites

Alzheimer's & Dementia, 2022
Alzheimer's disease (AD) is characterized by neurotoxic immuno‐inflammation concomitant with cytotoxic oligomerization of amyloid beta (Aβ) and tau, culminating in concurrent, interdependent immunopathic and proteopathic pathogeneses.
F. Meier‐Stephenson, V. Meier‐Stephenson, Michael D. Carter, Autumn Meek, Yanfei Wang, Luzhe Pan, Qian Chen, S. Jacobo, Fan Wu, Erhu Lu, G. Simms, Laural A. Fisher, Alaina J. McGrath, Virgil Fermo, C. Barden, H. Clair, Todd N. Galloway, Arun A. Yadav, Valérie Campagna-Slater, Mark Hadden, M. Reed, Marcia M. Taylor, Brendan Kelly, Elena Diez-Cecilia, Igri Kolaj, Clarissa Santos, Imindu Liyanage, B. Sweeting, P. Stafford, Robert Boudreau, G. A. Reid, R. Noyce, Leanne Stevens, Agnieszka Staniszewski, Hong Zhang, M. R. Murty, P. Lemaire, S. Chardonnet, Christopher D Richardson, V. Gabélica, E. Depauw, Richard E. Brown, S. Darvesh, O. Arancio, Donald F. Weaver   +44 more
semanticscholar   +1 more source

Tryptophan Metabolites at the Crossroad of Immune-Cell Interaction via the Aryl Hydrocarbon Receptor: Implications for Tumor Immunotherapy

International Journal of Molecular Sciences, 2021
The Aryl hydrocarbon receptor (AhR) is a critical regulator of both innate and adaptive immune responses, with potent immunomodulatory effects that makes this receptor an attractive molecular target for novel therapeutics. Accumulating evidence indicates
M. Gargaro, Giorgia Manni, Giulia Scalisi, P. Puccetti, F. Fallarino   +4 more
semanticscholar   +1 more source

Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

iScience, 2022
Summary: A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation.
Josephine Brown, Georges Abboud, Longhuan Ma, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Jean Lee, Weidan Peng, Joy Cagmat, Tamas Faludi, Mansour Mohamadzadeh, Timothy Garrett, Laura Mandik-Nayak, Alexander Chervonsky, Andras Perl, Laurence Morel   +15 more
doaj   +1 more source

Circulating tryptophan metabolites and risk of colon cancer: results from case-control and prospective cohort studies

International Journal of Cancer, 2021
Dysregulation of tryptophan metabolism has been linked to colorectal tumorigenesis; however, epidemiological studies investigating tryptophan metabolites in relation to colorectal cancer risk are limited.
N. Papadimitriou, M. Gunter, N. Murphy, Audrey Gicquiau, D. Achaintre, S. Brezina, Tanja Gumpenberger, A. Baierl, J. Ose, A. Geijsen, E. V. van Roekel, A. Gsur, B. Gigic, N. Habermann, C. Ulrich, E. Kampman, M. Weijenberg, P. Ueland, R. Kaaks, V. Katzke, V. Krogh, B. Bueno-de-Mesquita, E. Ardanaz, R. Travis, M. Schulze, María-José Sánchez, S. Colorado-Yohar, E. Weiderpass, A. Scalbert, P. Keski-Rahkonen   +29 more
semanticscholar   +1 more source