Results 31 to 40 of about 855,125 (282)

Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs

Animal Nutrition, 2022
Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu, Dongming Yu, Jing Sun, Xiaoyan Wu, Zhongquan Xin, Baichuan Deng, Lijuan Fan, Jian Fu, Liangpeng Ge, Wenkai Ren   +9 more
doaj   +1 more source

Peripheral tryptophan and serotonin and kynurenine pathways in major depression: A case-control study

European Psychiatry, 2021
Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression.
R. Colle, C. Verstuyft, D. David, P. Chanson, E. Corruble   +4 more
doaj   +1 more source

Tryptophan metabolism as bridge between gut microbiota and brain in chronic social defeat stress-induced depression mice

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundsGut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This study was conducted to explore the relationships between gut microbiota and host’s metabolism in ...
Jing Xie, Wen-tao Wu, Jian-jun Chen, Qi Zhong, Dandong Wu, Lingchuan Niu, Sanrong Wang, Yan Zeng, Ying Wang   +8 more
doaj   +1 more source

Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury

Cell Death and Disease, 2023
Glaucoma is the major cause of irreversible blindness in the world characterized by progressive retinal neurodegeneration, in which local inflammation in retina is involved in persistent loss of retinal ganglion cells (RGCs).
Yijie Yang, Ning-Lu Wang, Li Xu, Yixin Liu, Lulu Huang, Mengyang Gu, Yue Wu, Wenyi Guo, Hao Sun   +8 more
semanticscholar   +1 more source

LC-MS/MS-Based Profiling of Tryptophan-Related Metabolites in Healthy Plant Foods

Molecules, 2020
Food plants contain hundreds of bioactive phytochemicals arising from different secondary metabolic pathways. Among these, the metabolic route of the amino acid Tryptophan yields a large number of plant natural products with chemically and ...
Sara Vitalini, Michele Dei Cas, Federico Maria Rubino, Ileana Vigentini, Roberto Foschino, Marcello Iriti, Rita Paroni   +6 more
doaj   +1 more source

Serum Tryptophan Metabolites are Associated with Erosive Hand Osteoarthritis and Pain: Results from the DIGICOD Cohort.

Osteoarthritis and Cartilage, 2023
OBJECTIVE To investigate host and gut-microbiota related Tryptophan metabolism in hand osteoarthritis (HOA). METHODS The baseline serum concentration of 20 Tryptophan metabolites was measured in 416 HOA patients in a cross-sectional analysis of the ...
M. Binvignat, P. Emond, F. Mifsud, B. Miao, A. Courties, A. Lefèvre, E. Maheu, M. Crema, D. Klatzmann, M. Kloppenburg, P. Richette, A. Butte, E. Mariotti-Ferrandiz, F. Berenbaum, H. Sokol, J. Sellam   +15 more
semanticscholar   +1 more source

Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress

Heliyon, 2023
Tryptophan and its derived metabolites have been assumed to play important roles in the development and survival of organisms. However, the links of tryptophan and its derived metabolites to temperature change remained largely cryptic.
Yonghong Chen, Xiaoyu Yang, Longlong Zhang, Qunfu Wu, Shuhong Li, Jianghui Gou, Jiangbo He, Keqin Zhang, Shenghong Li, Xuemei Niu   +9 more
doaj   +1 more source

Tryptophan intake, not always the more the better

Frontiers in Nutrition, 2023
ObjectivesTo investigate the effects of excessive tryptophan intake on the body and the effects of tryptophan metabolism-related aryl hydrocarbon receptor (AhR) pathway in healthy rats and chronic kidney disease rats, to study the adverse effects of ...
Dongmei Hu, Junyi Liu, Wanlin Yu, Chuan Li, Chuan Li, Lihua Huang, Lihua Huang, Wei Mao, Wei Mao, Zhaoyu Lu, Zhaoyu Lu   +10 more
doaj   +1 more source

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation

International Journal of Tryptophan Research, 2023
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that plays an integral role in homeostatic maintenance by regulating cellular functions such as cellular differentiation, metabolism, barrier function, and immune response. An
E. W. Morgan, Fangcong Dong, Andrew J. Annalora, I. Murray, Trenton M. Wolfe, Reece Erickson, Krishne Gowda, Shantu Amin, K. Petersen, P. Kris-Etherton, C. Marcus, S. Walk, A. Patterson, G. Perdew   +13 more
semanticscholar   +1 more source

Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice

Italian Journal of Pediatrics, 2019
Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121,
Amelia Licari, Dietmar Fuchs, Gianluigi Marseglia, Giorgio Ciprandi   +3 more
doaj   +1 more source