Results 21 to 30 of about 855,125 (282)
Gut Microbes, 2020 Tryptophan (Trp) is not only a nutrient enhancer but also has systemic effects. Trp metabolites signaling through the well-known aryl hydrocarbon receptor (AhR) constitute the interface of microbiome-gut-brain axis. However, the pathway through which Trp
Ning Ma, Ting He, Lee J Johnston
exaly +2 more sources
Tryptophan metabolites profile predict remission with dietary therapy in pediatric Crohn’s disease [PDF]
Therapeutic Advances in GastroenterologyBackground: Crohn’s disease (CD) exclusion diet combined with partial enteral nutrition (CDED + PEN) or exclusive enteral nutrition (EEN) is effective in inducing remission in mild-to-moderate pediatric CD. Although CDED + PEN is better tolerated and has
Rotem Sigall Boneh +12 more
doaj +2 more sources
Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology
Nature CommunicationsWhile it has been suggested that alterations in the composition of gut microbial metabolites may play a causative role in the pathophysiology of autism spectrum disorder (ASD), it is not known how gut microbial metabolites are associated with ASD ...
Lisa Aziz-Zadeh +11 more
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TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome
Metabolites, 2021 Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu +5 more
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Frontiers in Cellular and Infection Microbiology, 2023 Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan +23 more
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Gut microbiome and metabolic activity in type 1 diabetes: An analysis based on the presence of GADA
Frontiers in Endocrinology, 2022 ObjectiveType 1 diabetes (T1D) progression is affected by circulating glutamic acid decarboxylase antibody (GADA) that persist for many years. This study aimed at investigating whether and how the gut microbiome and its correlated metabolites change in ...
Sihui Luo +10 more
doaj +1 more source
The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites
Scientific Reports, 2022 This study aims to explore the immediate effects of bariatric surgery on serum tryptophan–kynurenine pathway metabolites in individuals with type 2 diabetes and BMI > 30.
Kai Tai Derek Yeung +7 more
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Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis
Cells, 2022 Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such as indole-3-lactate (ILA), indole-3-acrylate (IAC), indole-3-propionate
Xiaomin Su, Yunhuan Gao, Rongcun Yang
semanticscholar +1 more source
Modulation of T cells by tryptophan metabolites in the kynurenine pathway.
TIPS - Trends in Pharmacological Sciences, 2023 Lymphocytes maturing in the thymus (T cells) are key factors in adaptive immunity and the regulation of inflammation. The kynurenine pathway of tryptophan metabolism includes several enzymes and compounds that can modulate T cell function, but ...
T. Stone, Richard O. Williams
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Journal of molecular medicine, 2023 Gut microbiota in interaction with intestinal host tissues influences many brain functions and microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric conditions and Alzheimer’s disease (AD). l -tryptophan metabolites and short-
A. Salminen
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