Results 11 to 20 of about 855,125 (282)

Tryptophan metabolites get the gut moving. [PDF]

Cell Host & Microbe, 2021
How gut microbes can regulate the enteric nervous system and gut-brain communications is a field of intense research. In this issue of Cell Host & Microbe, Ye et al.
N. Benech, N. Rolhion, H. Sokol
semanticscholar   +5 more sources

Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2

Journal of Translational Medicine, 2023
Background Lactobacillus has been demonstrated to serve a protective role in intestinal injury. However, the relationship between Lactobacillus murinus (L. murinus)-derived tryptophan metabolites and intestinal ischemia/reperfusion (I/R) injury yet to be
Fang-Ling Zhang, Xiao-Wei Chen, Yi-Fan Wang, Zhen Hu, Wen-Juan Zhang, Bo-Wei Zhou, Peng-Fei Ci, Ke-Xuan Liu   +7 more
doaj   +2 more sources

Integrative analysis of the gut microbiota and faecal and serum short-chain fatty acids and tryptophan metabolites in patients with cirrhosis and hepatic encephalopathy

Journal of Translational Medicine, 2023
Objective The purpose of this study was to describe the changes in the gut microbiome of patients with cirrhosis and hepatic encephalopathy (HE), as well as quantify the variations in short-chain fatty acid (SCFA) and tryptophan metabolite levels in ...
Qiang Wang, Chengxin Chen, Shi Zuo, Kun Cao, Haiyang Li   +4 more
doaj   +2 more sources

Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses

Plant Communications
Plants are frequently threatened by diverse stresses that severly impact their health and constrain crop productivity worldwide. Metabolic regulation serves as an important strategy for enhancing plant stress tolerance.
Shuang Wang, Xia Zhang, Dao-Hong Gong, Qiu-Qian Huang, W.M.W.W. Kandegama, Milen I. Georgiev, Yang-Yang Gao, Pan Liao, Ge-Fei Hao   +8 more
doaj   +2 more sources

High performance liquid chromatography–tandem mass spectrometry quantification of tryptophan metabolites in human serum and stool – Application to clinical cohorts in Inflammatory Bowel Diseases

Journal of Chromatography A, 2022
Tryptophan, an essential amino acid, and its metabolites are involved in many physiological processes including neuronal functions, immune system, and gut homeostasis.
Aurore Desmons, Lydie Humbert, Thibaut Eguether   +2 more
exaly   +2 more sources

Commensal-derived tryptophan metabolites fortify the skin barrier: Insights from a 50-species gnotobiotic model of human skin microbiome. [PDF]

Cell Chem Biol
Summary The epidermal barrier defends the body against dehydration and harmful substances. The commensal microbiota is essential for proper differentiation and repair of the epidermal barrier, an effect mediated by the aryl hydrocarbon receptor (AHR ...
Uberoi A, Murga-Garrido SM, Bhanap P, Campbell AE, Knight SAB, Wei M, Chan A, Senay T, Tegegne S, White EK, Sutter CH, Mesaros C, Sutter TR, Grice EA.   +13 more
europepmc   +2 more sources

Microbial Tryptophan Metabolites Ameliorate Ovariectomy-Induced Bone Loss by Repairing Intestinal AhR-Mediated Gut-Bone Signaling Pathway. [PDF]

Adv Sci (Weinh)
Microbial tryptophan (Trp) metabolites acting as aryl hydrocarbon receptor (AhR) ligands are shown to effectively improve metabolic diseases via regulating microbial community.
Chen C, Cao Z, Lei H, Zhang C, Wu M, Huang S, Li X, Xie D, Liu M, Zhang L, Chen G.   +10 more
europepmc   +2 more sources

Tryptophan metabolites and gut microbiota play an important role in pediatric migraine diagnosis. [PDF]

J Headache Pain
Background The pathogenesis of pediatric migraine remains unclear and presents challenges in diagnosis. Recently, growing evidence has indicated that the gut microbiota can exert modulatory functions at the gut-brain axis by directly or indirectly ...
Liu J, Xi K, Zhang L, Han M, Wang Q, Liu X.   +5 more
europepmc   +2 more sources

Tryptophan Metabolites in the Progression of Liver Diseases. [PDF]

Biomolecules
The aim of this study was to investigate the levels of various tryptophan metabolites in patients with alcoholic liver disease (ALD) and metabolic-associated fatty liver disease (MAFLD) at different stages of the disease. The present study included 44 patients diagnosed with MAFLD, 40 patients diagnosed with ALD, and 14 healthy individuals in the ...
Reshetova M, Markin P, Appolonova S, Yunusov I, Zolnikova O, Bueverova E, Dzhakhaya N, Zharkova M, Poluektova E, Maslennikov R, Ivashkin V.   +10 more
europepmc   +4 more sources

Altered milk tryptophan and tryptophan metabolites in women living with HIV. [PDF]

Nat Commun
Abstract Children born to women living with HIV (WLWH) suffer increased morbidity and, in low-income settings, have two to three times the mortality of infants born to women without HIV. The basis for this increase remains elusive.
Tobin NH, Li F, Zhu W, Ferbas KG, Sleasman JW, Raftery D, Kuhn L, Aldrovandi GM.   +7 more
europepmc   +3 more sources