Results 51 to 60 of about 855,125 (282)

Microanalysis of Tryptophan Metabolites

YAKUGAKU ZASSHI, 1997
In tryptophan metabolites, 3-hydroxykynurenine and 3-hydroxyanthranilic acid have been reported to show a carcinogenic action to mice bladder and the relation of the metabolites to human bladder cancer has been discussed. We developed methods for the fluorometric assay of these compounds and showed that the excretion of 3-hydroxyanthranilic acid ...
openaire   +3 more sources

Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites

Gut microbes
With the increasing of aging population and the consumption of high-fat diets (HFD), the incidence of Alzheimer’s disease (AD) has skyrocketed.
Sen Li, Yuwei Cai, Tong Guan, Yu Zhang, Kai Huang, Ze Zhang, Wangqing Cao, Xiao-long Guan   +7 more
semanticscholar   +1 more source

Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The gut microbiome comprises trillions of microorganisms that inhabit the mammalian intestines. These microbes regulate many aspects of host physiology, including defense mechanisms against factors that contribute to inflammatory bowel ...
Samantha A. Scott, Jingjing Fu, Pamela V. Chang   +2 more
semanticscholar   +1 more source

Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease

Journal of Clinical Investigation, 2021
Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular damage, their role in PAD remains elusive.
Nkiruka V. Arinze, Wenqing Yin, Saran Lotfollahzadeh, M. Napoleon, Sean Richards, Joshua Walker, Mostafa E. Belghasem, Jonathan D Ravid, Mohamed Hassan Kamel, S. Whelan, Norman Lee, J. Siracuse, S. Anderson, A. Farber, D. Sherr, J. Francis, N. Hamburg, N. Rahimi, V. Chitalia   +18 more
semanticscholar   +1 more source

Excretion of tryptophan metabolites in Friedreich's ataxia [PDF]

Journal of Clinical Pathology, 1965
The overnight urinary excretions of the tryptophan metabolites 5-hydroxy indole acetic acid (5HIAA), indole acetic acid (IAA), indoxyl sulphate, and kynurenine were determined in 10 cases of Friedreich's ataxia and in 11 controls. Levels of 5HIAA and IAA were slightly lower and of indoxyl sulphate higher than in the controls but within normal limits ...
N, Robinson, G, Curzon, P, Theaker
openaire   +2 more sources

Synbiotics of Bifidobacterium breve MCC1274 and lactulose enhances production of tryptophan metabolites in fermented human fecal communities.

Food Research International, 2022
Probiotics and prebiotics have beneficial effects on host physiology via metabolites from the gut microbiota in addition to their own. Here, we used a pH-controlled single-batch fermenter as a human gut microbiota model.
N. Hashikura, Ryuta Murakami, T. Sakurai, A. Horigome, K. Toda, Jin-zhong Xiao, T. Odamaki   +6 more
semanticscholar   +1 more source

The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism

Metabolites, 2023
Tryptophan is metabolized along three main metabolic pathways, namely the kynurenine, serotonin and indole pathways. The majority of tryptophan is transformed via the kynurenine pathway, catalyzed by tryptophan-2,3-dioxygenase or indoleamine-2,3 ...
Anna Haduch, Ewa Bromek, Wojciech Kuban, Władysława Anna Daniel   +3 more
doaj   +1 more source

Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Biomedicines, 2021
Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits.
M. Simonato, S. Dall'acqua, Caterina Zilli, S. Sut, R. Tenconi, N. Gallo, P. Sfriso, L. Sartori, F. Cavallin, U. Fiocco, P. Cogo, Paolo Agostinis, A. Aldovini, D. Bruttomesso, R. Marcolongo, S. Comai, A. Baritussio   +16 more
semanticscholar   +1 more source

Chicken-eaters and pork-eaters have different gut microbiota and tryptophan metabolites

Scientific Reports, 2021
This study was aimed to evaluate the differences in the composition of gut microbiota, tryptophan metabolites and short-chain fatty acids in feces between volunteers who frequently ate chicken and who frequently ate pork.
Jie Shi, Di Zhao, Fan Zhao, Chong Wang, G. Zamaratskaia, Chunbao Li   +5 more
semanticscholar   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source