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Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024) [PDF]

Molecules
Indole derivatives have become an important class of compounds in medicinal chemistry, recognized for their wide-ranging biological activities and therapeutic potential.
Xingyou Mo, Devendra Pratap Rao, Kirandeep Kaur, Roket Hassan, Ahmed S. Abdel-Samea, Sara Mahmoud Farhan, Stefan Bräse, Hamada Hashem   +7 more
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A brief review of the biological potential of indole derivatives

Future Journal of Pharmaceutical Sciences, 2020
Background Various bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds
Sunil Kumar, Ritika
doaj   +2 more sources

Synthesis, antioxidant and cytoprotective activity evaluation of C-3 substituted indole derivatives

Scientific Reports, 2021
A series of fifteen indole derivatives substituted at the C-3 position were synthesized and characterized. The antioxidant activity of all derivatives was investigated by three in vitro antioxidant assays, and the derivative with ...
Beata Jasiewicz, Weronika Kozanecka-Okupnik, Michał Przygodzki, Beata Warżajtis, Urszula Rychlewska, Tomasz Pospieszny, Lucyna Mrówczyńska   +6 more
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Indole Derivatives Bearing Imidazole, Benzothiazole-2-Thione or Benzoxazole-2-Thione Moieties—Synthesis, Structure and Evaluation of Their Cytoprotective, Antioxidant, Antibacterial and Fungicidal Activities

Molecules, 2023
In the search for new bioactive compounds, a methodology based on combining two molecules with biological properties into a new hybrid molecule was used to design and synthesize of a series of ten indole derivatives bearing imidazole, benzothiazole-2 ...
Beata Jasiewicz, Karolina Babijczuk, Beata Warżajtis, Urszula Rychlewska, Justyna Starzyk, Grzegorz Cofta, Lucyna Mrówczyńska   +6 more
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Limosilactobacillus reuteri Attenuates Atopic Dermatitis via Changes in Gut Bacteria and Indole Derivatives from Tryptophan Metabolism

International Journal of Molecular Sciences, 2022
Gut bacteria are closely associated with the development of atopic dermatitis (AD) due to their immunoregulatory function. Indole derivatives, produced by gut bacteria metabolizing tryptophan, are ligands to activate the aryl hydrocarbon receptor (AHR ...
Zhifeng Fang, Tong Pan, Hongchao Wang
exaly   +2 more sources

Utilizing Some Indole Derivatives to Control Mild Steel Corrosion in Acidic Environments: Electrochemical and Theoretical Methods [PDF]

Molecules
Ethyl 3-formyl-1H-indol-2-carboxylate (FIC) and 2-(4-methoxyphenyl)-2,4-dihydropyrrolo [3,4-b]indol-3-ol (MPI) were synthesized as indole derivatives. The chemical structures of FIC and MPI were established through analytical and spectroscopic techniques.
Eid E. Salama, Saad Alrashdi, Ahmed T. A. Boraei, Salah Eid, Islam Gomaa, Ehab S. Gad, Ahmed A. Elhenawy, Hashem Nady   +7 more
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Indole Derivatives Biosynthesis in Bifidobacterium longum subsp. infantis and the Tryptophan Substrate Availability [PDF]

Microbial Biotechnology
The metabolic processes of Bifidobacterium longum subsp. infantis, an early coloniser of the human gut, are essential for gut health, mainly due to the production of indole derivatives from tryptophan. This study investigates the capacity of B.
Shi‐Min Zhang, Hui‐Chu Wu, Jia‐He Hung, Shir‐Ly Huang   +3 more
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New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases

Frontiers in Pharmacology, 2021
The interaction between host and microorganism widely affects the immune and metabolic status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan catalyzed by intestinal microorganisms.
Xiaojing Li, Binbin Zhang, Yiyang Hu, Yiyang Hu, Yu Zhao   +4 more
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Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults [PDF]

Nutrition Journal
Background Although emerging evidence suggests that indole derivatives, microbial metabolites of tryptophan, may improve cardiometabolic health, the effective metabolites remain unclear.
Yutong Pan, Yamin Li, Zhaohong Peng, Xiaoyu Zhang, Shu Ye, Na Chen, Zhuang Zhang, Wanshui Yang   +7 more
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Synthesis of indole-based propellane derivatives via Weiss–Cook condensation, Fischer indole cyclization, and ring-closing metathesis as key steps

Beilstein Journal of Organic Chemistry, 2013
A variety of highly functionalized indole-based [n.3.3]propellane derivatives is described. The synthesis of the propellane derivatives involves a Weiss–Cook condensation, a Fischer indole cyclization, and a ring-closing metathesis as key steps.
Sambasivarao Kotha, Ajay Kumar Chinnam, Arti Tiwari   +2 more
doaj   +2 more sources