Results 31 to 40 of about 1,668,623 (259)

Synthesis, molecular docking, and anti-breast cancer study of 1-H-indol-3-Carbohydrazide and their derivatives

Results in Chemistry
A prominent heterocyclic system found in medications and natural goods is indoles. Due to the significance of this important ring system, a fresh batch of unique indole derivatives was created using indole carbohydrazide.
Zainab H. Mahdi, Tahseen A. Alsalim, Heider A. Abdulhussein, Ahmed A. Majed, Sabah Abbas   +4 more
doaj   +1 more source

INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW

, 2020
Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively attached to produce novel drugs. Among various heterocyclic compounds,  nitrogen-based heterocycles have been extensively investigated as they constitute the core ...
Harshita Sachdeva, Jaya Mathur, A. Guleria   +2 more
semanticscholar   +1 more source

Endophytic fungus Falciphora oryzae promotes lateral root growth by producing indole derivatives after sensing plant signals.

Plant, Cell and Environment, 2020
The endophytic fungus Falciphora oryzae was initially isolated from wild rice (Oryza granulata) and colonizes many crop species and promotes plant growth. However, the molecular mechanisms underlying F. oryzae-mediated growth promotion are still unknown.
Xun Sun, Ning Wang, Ping Li, Zhiyan Jiang, Xiaoyu Liu, Mengcen Wang, Zhen-zhu Su, Chulong Zhang, Fucheng Lin, Yan Liang   +9 more
semanticscholar   +1 more source

One-pot Lewis acid assisted synthesis of indole-3-sulfonamide and imidazo[1,2-a]pyridine-3-sulfonamide using Burgess reagent in a microwave reactor

Results in Chemistry, 2023
Indole-3-sulfonamides and imidazo[1,2-a]pyridine-3-sulfonamides have served as useful derivatives for development of useful therapeutics and agrochemicals.
Sivalenka Vijayasaradhi, Valluri Muralikrishna, Ravula Srinivas, Cherukumalli Purna Koteswara Rao, Kotipalli Yesu Prasad, Byreddy Prasad, Baman Khanna   +6 more
doaj   +1 more source

Synthesis of Cyclobutane-Fused Angular Tetracyclic Spiroindolines via Visible-Light-Promoted Intramolecular Dearomatization of Indole Derivatives.

Journal of the American Chemical Society, 2019
An intramolecular dearomatization of indole derivatives based on visible-light-promoted [2+2] cycloaddition was achieved via energy transfer mechanism.
Min Zhu, C. Zheng, Xiao Zhang, S. You
semanticscholar   +1 more source

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

Scientific Reports, 2021
The ATP-binding cassette transporter ABCG2 mediates the efflux of several chemotherapeutic drugs, contributing to the development of multidrug resistance (MDR) in many cancers.
Diogo Henrique Kita, Nathalie Guragossian, Ingrid Fatima Zattoni, Vivian Rotuno Moure, Fabiane Gomes de Moraes Rego, Sabrina Lusvarghi, Thomas Moulenat, Billel Belhani, Geraldo Picheth, Sofiane Bouacida, Zouhair Bouaziz, Christelle Marminon, Malika Berredjem, Joachim Jose, Marcos Brown Gonçalves, Suresh V. Ambudkar, Glaucio Valdameri, Marc Le Borgne   +17 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents

Current Research in Pharmacology and Drug Discovery, 2022
Indole-containing small molecules have been reported to have diverse pharmacological activities. The aromatic heterocyclic scaffold, which resembles various protein structures, has received attention from organic and medicinal chemists.
Nilesh Gajanan Bajad, Sudhir Kumar Singh, Sushil Kumar Singh, Tryambak Deo Singh, Meenakshi Singh   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source