Results 121 to 130 of about 487,159 (190)

Synthesis of 3-Substituted Indole by AlCl3-Promoted Reaction of α,β-unsaturated Ketone with Indole

, 2014
A one-pot Lewis acid-A one-pot Lewis acid-promoted reaction condition of β,γ-unsaturated ketone with indole was developed for the synthesis of 3-substituted indoles with moderate to good yields.
Lee, Shih-Yuan, Lee, Shih-Yuan; Wu, Yu-Chi; Chang, Yu-Ting; Wang, Bo-Cheng   +1 more
core   +1 more source

Overexpression of RpKTI2 from Robinia pseudoacacia Affects the Photosynthetic Physiology and Endogenous Hormones of Tobacco

Plants
Kunitz trypsin inhibitor genes play important roles in stress resistance. In this study, we investigated RpKTI2 cloned from Robinia pseudoacacia and its effect on tobacco.
Jian Zhou, Pengxiang Die, Songyan Zhang, Xiaoya Han, Chenguang Wang, Peipei Wang   +5 more
doaj   +1 more source

β-[3-NITROPHENYL]-β-[ANTHRON-(9)-YL-(10)]-PROPIONIC ACID AND ITS DERIVATIVES

, 1934
β-[3-Nitrophenvl]-β-[anthron-(9)-yl-(10)]-propionic acid, unlike β-phenyl-β-[anthron-(9)-yl-(10]-propionic acid (2, 3), was not found to undergo cyclisation to form a hydrindone derivative when treated with aluminium chloride.
Paul E. Gagnon, Alexandre Vachon, John Kane   +2 more
core   +1 more source

UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model

, 2011
Since the development and prognosis of alcohol-induced liver disease (ALD) vary significantly with genetic background, identification of a genetic background-independent noninvasive ALD biomarker would significantly improve screening and diagnosis.
Manna, Soumen K, Yang, Qian, Gonzalez, Frank J, Kristopher W. Krausz, Patterson, Andrew D, Fornace, Albert J, Albert J. Fornace, Frank J. Gonzalez, Andrew D. Patterson, Krausz, Kristopher W, Soumen K. Manna, Idle, Jeffrey R, Qian Yang, Jeffrey R. Idle   +13 more
core   +1 more source

Regioselective Synthesis of 3-(1H-indol-3-yl)-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic Acids: A Route to Hydroxyfuroic Acid Based Insulin Receptor Activators

, 2012
[[abstract]]A new class of insulin receptor activator with a hydroxyfuroic acid in place of a hydroxyquinone moiety is reported. The synthesis of 3-(1H-indol-3-yl)-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic acids (26–30) requires seven major steps.
Chou, Shan-Yen;蔡建鈞;Tsai, Henry Jan-Jen
core  

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis

, 2019
Indole propionic acid (IPA), produced by the gut microbiota, is active against Mycobacterium tuberculosis in vitro and in vivo. However, its mechanism of action is unknown.
Dereje Abate Negatu, Yoshiyuki Yamada, Véronique Dartois, Yamada, Y., Mei Lin Go, Thomas Dick, Gengenbacher, M., Matthew Zimmerman, Yu Xi, Uday Ganapathy, Negatu, D.A., Dartois, V., Zimmerman, M., Martin Gengenbacher, Xi, Y., Go, M.L., Dick, T., Ganapathy, U.   +17 more
core   +1 more source

In vivo study of the antitumor activity of indole-3-propionic acid and its combination with chemotherapy drugs

Siberian journal of oncology
Background . Colorectal cancer (CRC) is characterized by high mortality and the development of therapy resistance. Indole-3-propionic acid (IPA), a gut microbiota-derived metabolite, shows promise in treating colorectal cancer (CRC) by strengthening antitumor immunity and improving chemotherapy effcacy.
D. A. Lysenko, V. E. Kolesnikov, A. V. Galina, L. Yu. Vladimirova, A. N. Shevchenko, D. V. Khodakova, M. A. Kuznetsova, A. A. Shulga, S. N. Vlasov   +8 more
openaire   +1 more source

Development of [³H]2-Carboxy-4,6-dichloro‑1H‑indole-3-propionic Acid ([³H]PSB-12150): A Useful Tool for Studying GPR17

, 2016
The recently described synthetic GPR17 agonist 2-carboxy-4,6-dichloro-1H-indole-3-propionic acid (1) was prepared in tritium-labeled form by catalytic hydrogenation of the corresponding propenoic acid derivative 8 with tritium gas.
Meryem Köse (1822522), Kirsten Ritter (1822525), Katharina Thiemke (1822519), Christa E. Müller (1550497), Evi Kostenis (176797), Michel Gillard (261248)   +5 more
core   +1 more source

Synthesis of 2-aminopropyl-3-indole–acetic(propionic) acid derivatives

ARKIVOC, 2003
Sophie-Isabelle Bascop, Jean-Yves Laronze, Janos Sapi   +2 more
doaj   +1 more source

Roux‐en‐Y gastric bypass surgery decreases intestinal aryl hydrocarbon receptor signaling in male mice

Physiological Reports
The impact of Roux‐en‐Y gastric bypass (RYGB) on indole metabolism and AhR signaling is poorly understood. Therefore, we tested the hypothesis that RYGB changes the indole metabolite profile in the gut, leading to changes in AhR signaling.
Annie Wang, Madelynn E. Agabao‐Tucker, Michael L. Goodson, Allison K. Ehrlich, Bethany P. Cummings   +4 more
doaj   +1 more source